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Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation

BACKGROUND: Despite improvement in the surgical procedure and strictly following the guidelines for mitral valve replacement (MVR), left ventricular dysfunction still occurs. Novel echocardiographic indices can predict development of LV (left ventricle) dysfunction post MVR. LV-GLS (global longitudi...

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Autores principales: Shanishwara, Parth, Vyas, Pooja, Joshi, Hasit, Patel, Iva, Dubey, Gajendra, Patel, Jignesh, Sharma, Shubham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Heart Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671149/
https://www.ncbi.nlm.nih.gov/pubmed/36447601
http://dx.doi.org/10.37616/2212-5043.1315
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author Shanishwara, Parth
Vyas, Pooja
Joshi, Hasit
Patel, Iva
Dubey, Gajendra
Patel, Jignesh
Sharma, Shubham
author_facet Shanishwara, Parth
Vyas, Pooja
Joshi, Hasit
Patel, Iva
Dubey, Gajendra
Patel, Jignesh
Sharma, Shubham
author_sort Shanishwara, Parth
collection PubMed
description BACKGROUND: Despite improvement in the surgical procedure and strictly following the guidelines for mitral valve replacement (MVR), left ventricular dysfunction still occurs. Novel echocardiographic indices can predict development of LV (left ventricle) dysfunction post MVR. LV-GLS (global longitudinal strain) derived from speckle tracking echocardiography, has been proposed as a novel measure to better depict latent LV dysfunction. METHODS: A total of 100 patients with severe MR (mitral regurgitation) planned for MVR were included. Speckle tracking echocardiography was performed at baseline and at follow up post MVR. ROC (Receiver operating characteristics) curve was plotted to derive the cutoff value of LV-GLS for prediction of LV dysfunction post MVR. Univariate and multi variate regression was analyzed to predict the independent predictors of LV dysfunction after MVR. RESULTS: LV-GLS was decreased from baseline data (−19.9 vs. −17.7) in patients with LVEF <50% after MVR compared to patients with LVEF≥ 50%. Baseline value of LVESD (35.36 mm vs. 28.23 mm) and LVEDD (49.33 mm vs. 45.10 mm) were significantly higher in patients with LVEF<50% compared to LVEF ≥50% at 3 months follow up. A cutoff value of GLS −19% with sensitivity of 80.3% and specificity of 75.7% was associated in patients with LV dysfunction after MVR. In multivariate regression model GLS < −19% (OR = 21.8, CI:6.61–82.4, P=<0.001) was an independent predictor of LV dysfunction post MVR. CONCLUSION: A GLS value of less than −19% was demonstrated as an independent predictor of short term LV dysfunction after mitral valve surgery, LVESD ≥40 mm was also verified additional parameter to predict the LV dysfunction post MVR.
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spelling pubmed-96711492022-11-28 Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation Shanishwara, Parth Vyas, Pooja Joshi, Hasit Patel, Iva Dubey, Gajendra Patel, Jignesh Sharma, Shubham J Saudi Heart Assoc Original Article BACKGROUND: Despite improvement in the surgical procedure and strictly following the guidelines for mitral valve replacement (MVR), left ventricular dysfunction still occurs. Novel echocardiographic indices can predict development of LV (left ventricle) dysfunction post MVR. LV-GLS (global longitudinal strain) derived from speckle tracking echocardiography, has been proposed as a novel measure to better depict latent LV dysfunction. METHODS: A total of 100 patients with severe MR (mitral regurgitation) planned for MVR were included. Speckle tracking echocardiography was performed at baseline and at follow up post MVR. ROC (Receiver operating characteristics) curve was plotted to derive the cutoff value of LV-GLS for prediction of LV dysfunction post MVR. Univariate and multi variate regression was analyzed to predict the independent predictors of LV dysfunction after MVR. RESULTS: LV-GLS was decreased from baseline data (−19.9 vs. −17.7) in patients with LVEF <50% after MVR compared to patients with LVEF≥ 50%. Baseline value of LVESD (35.36 mm vs. 28.23 mm) and LVEDD (49.33 mm vs. 45.10 mm) were significantly higher in patients with LVEF<50% compared to LVEF ≥50% at 3 months follow up. A cutoff value of GLS −19% with sensitivity of 80.3% and specificity of 75.7% was associated in patients with LV dysfunction after MVR. In multivariate regression model GLS < −19% (OR = 21.8, CI:6.61–82.4, P=<0.001) was an independent predictor of LV dysfunction post MVR. CONCLUSION: A GLS value of less than −19% was demonstrated as an independent predictor of short term LV dysfunction after mitral valve surgery, LVESD ≥40 mm was also verified additional parameter to predict the LV dysfunction post MVR. Saudi Heart Association 2022-11-02 /pmc/articles/PMC9671149/ /pubmed/36447601 http://dx.doi.org/10.37616/2212-5043.1315 Text en © 2022 Saudi Heart Association https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Shanishwara, Parth
Vyas, Pooja
Joshi, Hasit
Patel, Iva
Dubey, Gajendra
Patel, Jignesh
Sharma, Shubham
Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation
title Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation
title_full Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation
title_fullStr Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation
title_full_unstemmed Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation
title_short Role of Speckle Tracking Echocardiography to Predict Left Ventricular Dysfunction Post Mitral Valve Replacement Surgery for Severe Mitral Regurgitation
title_sort role of speckle tracking echocardiography to predict left ventricular dysfunction post mitral valve replacement surgery for severe mitral regurgitation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671149/
https://www.ncbi.nlm.nih.gov/pubmed/36447601
http://dx.doi.org/10.37616/2212-5043.1315
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