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Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infection

ACE2 and TMPRSS2 are crucial for SARS-CoV-2 entry into the cell. Although ACE2 facilitates viral entry, its loss leads to promoting the devastating clinical symptoms of COVID-19 disease. Thus, enhanced ACE2/TMPRSS2 expression is likely to increase predisposition of target cells to SARS-CoV-2 infecti...

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Detalles Bibliográficos
Autores principales:	Shahbaz, Shima, Oyegbami, Olaide, Saito, Suguru, Osman, Mohammed, Sligl, Wendy, Elahi, Shokrollah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671168/ https://www.ncbi.nlm.nih.gov/pubmed/36405732 http://dx.doi.org/10.3389/fimmu.2022.1021928

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