Reversion of methionine addiction of osteosarcoma cells to methionine independence results in loss of malignancy, modulation of the epithelial-mesenchymal phenotype and alteration of histone-H3 lysine-methylation

Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman Effect, is due to altered use of methionine for increased and aberrant transmethylation reactions. However, the linkage of methionine addiction and malignancy of cancer cells is incompletely understood. An isoge...

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Detalles Bibliográficos
Autores principales: Aoki, Yusuke, Han, Qinghong, Tome, Yasunori, Yamamoto, Jun, Kubota, Yutaro, Masaki, Noriyuki, Obara, Koya, Hamada, Kazuyuki, Wang, Justin D., Inubushi, Sachiko, Bouvet, Michael, Clarke, Steven G., Nishida, Kotaro, Hoffman, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671209/
https://www.ncbi.nlm.nih.gov/pubmed/36408173
http://dx.doi.org/10.3389/fonc.2022.1009548

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