Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages

A colloidal synthesis’ proof-of-concept based on the Bligh–Dyer emulsion inversion method was designed for integrating into lipid nanoparticles (LNPs) cell-permeating DNA antisense oligonucleotides (ASOs), also known as GapmeRs (GRs), for mRNA interference. The GR@LNPs were formulated to target brai...

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Detalles Bibliográficos
Autores principales: Calero, Macarena, Moleiro, Lara H., Sayd, Aline, Dorca, Yeray, Miquel-Rio, Lluis, Paz, Verónica, Robledo-Montaña, Javier, Enciso, Eduardo, Acción, Fernando, Herráez-Aguilar, Diego, Hellweg, Thomas, Sánchez, Luis, Bortolozzi, Analía, Leza, Juan C., García-Bueno, Borja, Monroy, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671215/
https://www.ncbi.nlm.nih.gov/pubmed/36406277
http://dx.doi.org/10.3389/fmolb.2022.887678

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