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Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study

Adhesions formation after surgery for congenital heart defects can complicate follow-up procedures due to bleeding from detached adhesion bands, injury to cardiac structures or large vessels, all of which do prolong operation times. The problem is enhanced by the fact that detached adhesions are pre...

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Autores principales: Cesnjevar, Robert, Purbojo, Ariawan, Haake, Claas, Laas, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671326/
https://www.ncbi.nlm.nih.gov/pubmed/36395120
http://dx.doi.org/10.1371/journal.pone.0277530
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author Cesnjevar, Robert
Purbojo, Ariawan
Haake, Claas
Laas, Joachim
author_facet Cesnjevar, Robert
Purbojo, Ariawan
Haake, Claas
Laas, Joachim
author_sort Cesnjevar, Robert
collection PubMed
description Adhesions formation after surgery for congenital heart defects can complicate follow-up procedures due to bleeding from detached adhesion bands, injury to cardiac structures or large vessels, all of which do prolong operation times. The problem is enhanced by the fact that detached adhesions are predilection sites for new adhesions setting off a downward spiral. 4DryField(®) PH gel barrier has demonstrated high efficacy in reducing postoperative adhesions in general surgical and gynecological studies. This retrospective controlled study of 22 patients evaluates whether these positive results can be confirmed in pediatric cardiac surgery. Adhesions were scored from photographs of follow-up interventions by an independent cardiac surgeon blinded to group assignment. The publication provides not only score numbers but also original photographs of all sites for better traceability and transparency. In addition, timesaving due to reduced adhesions was evaluated. Results show a significantly reduced adhesion score for the 4DryField(®) group. Importantly, this resulted in a significantly shorter period between skin incision and start of cardiopulmonary bypass. In addition, timesaving due reduced adhesion formation was evaluated. The use of 4DryField(®) was safe, although higher doses per kg were used than in adults.
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spelling pubmed-96713262022-11-18 Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study Cesnjevar, Robert Purbojo, Ariawan Haake, Claas Laas, Joachim PLoS One Research Article Adhesions formation after surgery for congenital heart defects can complicate follow-up procedures due to bleeding from detached adhesion bands, injury to cardiac structures or large vessels, all of which do prolong operation times. The problem is enhanced by the fact that detached adhesions are predilection sites for new adhesions setting off a downward spiral. 4DryField(®) PH gel barrier has demonstrated high efficacy in reducing postoperative adhesions in general surgical and gynecological studies. This retrospective controlled study of 22 patients evaluates whether these positive results can be confirmed in pediatric cardiac surgery. Adhesions were scored from photographs of follow-up interventions by an independent cardiac surgeon blinded to group assignment. The publication provides not only score numbers but also original photographs of all sites for better traceability and transparency. In addition, timesaving due to reduced adhesions was evaluated. Results show a significantly reduced adhesion score for the 4DryField(®) group. Importantly, this resulted in a significantly shorter period between skin incision and start of cardiopulmonary bypass. In addition, timesaving due reduced adhesion formation was evaluated. The use of 4DryField(®) was safe, although higher doses per kg were used than in adults. Public Library of Science 2022-11-17 /pmc/articles/PMC9671326/ /pubmed/36395120 http://dx.doi.org/10.1371/journal.pone.0277530 Text en © 2022 Cesnjevar et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cesnjevar, Robert
Purbojo, Ariawan
Haake, Claas
Laas, Joachim
Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study
title Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study
title_full Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study
title_fullStr Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study
title_full_unstemmed Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study
title_short Significant adhesion reduction and time saving in pediatric heart surgery with 4DryField PH: A retrospective, controlled study
title_sort significant adhesion reduction and time saving in pediatric heart surgery with 4dryfield ph: a retrospective, controlled study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671326/
https://www.ncbi.nlm.nih.gov/pubmed/36395120
http://dx.doi.org/10.1371/journal.pone.0277530
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