Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats

BACKGROUND: Diabetes mellitus is a chronic metabolic disorder which induces endothelial dysfunction and platelet activation. Eicosanoids produced from arachidonic acid regulate cellular and vascular functions. Sigma-1 receptors (S1R) are expressed in platelets and endothelial cells and S1R expressio...

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Detalles Bibliográficos
Autores principales: Váczi, Sándor, Barna, Lilla, Laczi, Krisztián, Tömösi, Ferenc, Rákhely, Gábor, Penke, Botond, Fülöp, Lívia, Bogár, Ferenc, Janáky, Tamás, Deli, Mária A., Mezei, Zsófia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671357/
https://www.ncbi.nlm.nih.gov/pubmed/36395179
http://dx.doi.org/10.1371/journal.pone.0265854

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