Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase

The ability of Mycobacterium tuberculosis (Mtb) to persist in its host may enable an evolutionary advantage for drug resistant variants to emerge. A potential strategy to prevent persistence and gain drug efficacy is to directly target the activity of enzymes that are crucial for persistence. We pre...

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Detalles Bibliográficos
Autores principales: Kim, Heung-Bok, Bacik, John-Paul, Wu, Ruilian, Jha, Ramesh K., Hebron, Michaeline, Triandafillou, Catherine, McCown, Joseph E., Baek, Nam-In, Kim, Jeong Han, Kim, Young Jae, Goulding, Celia W., Strauss, Charlie E. M., Schmidt, Jurgen G., Shetye, Gauri S., Ryoo, Sungweon, Jo, Eun-Kyeong, Jeon, Young Ho, Hung, Li-Wei, Terwilliger, Thomas C., Kim, Chang-Yub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671377/
https://www.ncbi.nlm.nih.gov/pubmed/36395154
http://dx.doi.org/10.1371/journal.pone.0277670

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