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Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes

BACKGROUND: This study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We recruited two hundred people with T2DM, and evaluat...

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Autores principales: Salavatizadeh, Marieh, Soltanieh, Samira, Poustchi, Hossein, Yari, Zahra, Shabanpur, Maryam, Mansour, Asieh, Khamseh, Mohammad E., Alaei-Shahmiri, Fariba, Hekmatdoost, Azita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671398/
https://www.ncbi.nlm.nih.gov/pubmed/36407541
http://dx.doi.org/10.3389/fnut.2022.1037851
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author Salavatizadeh, Marieh
Soltanieh, Samira
Poustchi, Hossein
Yari, Zahra
Shabanpur, Maryam
Mansour, Asieh
Khamseh, Mohammad E.
Alaei-Shahmiri, Fariba
Hekmatdoost, Azita
author_facet Salavatizadeh, Marieh
Soltanieh, Samira
Poustchi, Hossein
Yari, Zahra
Shabanpur, Maryam
Mansour, Asieh
Khamseh, Mohammad E.
Alaei-Shahmiri, Fariba
Hekmatdoost, Azita
author_sort Salavatizadeh, Marieh
collection PubMed
description BACKGROUND: This study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We recruited two hundred people with T2DM, and evaluated their liver steatosis using Fibroscan. Dietary intakes of participants were assessed using a validated food frequency questionnaire. DTAC was computed via ferric reducing antioxidant power (FRAP). RESULTS: In the crude model, no statistically significant association was found between DTAC and the odds of NAFLD in people with diabetes. However, after adjustment for potential confounders including age, gender, diabetes duration, smoking status, physical activity, BMI, waist circumference, and energy, the most reduced adjusted OR was indicated for the third tertile vs. the first one (OR: 0.28, 95% CI: 0.09–0.81, P = 0.02), meaning that diabetic patients in the third tertile of DTAC had 72% decreased risk of NAFLD in comparison to those in the first one. The relationship was remained significant after additional adjustment for HOMA-IR, HbA1c, serum Triglyceride (TG), and low-density lipoprotein-cholesterol (LDL) levels (OR: 0.29, 95% CI: 0.09–0.93, P = 0.03). Importantly, a dose-response pattern was demonstrated for DTAC and risk of NAFLD (P = 0.04). CONCLUSION: Higher DTAC was related with a decreased risk of NAFLD in individuals with diabetes.
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spelling pubmed-96713982022-11-18 Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes Salavatizadeh, Marieh Soltanieh, Samira Poustchi, Hossein Yari, Zahra Shabanpur, Maryam Mansour, Asieh Khamseh, Mohammad E. Alaei-Shahmiri, Fariba Hekmatdoost, Azita Front Nutr Nutrition BACKGROUND: This study was conducted to evaluate possible associations between Dietary Total Antioxidant Capacity (DTAC) and odds of non-alcoholic fatty liver disease (NAFLD) in people with type-2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We recruited two hundred people with T2DM, and evaluated their liver steatosis using Fibroscan. Dietary intakes of participants were assessed using a validated food frequency questionnaire. DTAC was computed via ferric reducing antioxidant power (FRAP). RESULTS: In the crude model, no statistically significant association was found between DTAC and the odds of NAFLD in people with diabetes. However, after adjustment for potential confounders including age, gender, diabetes duration, smoking status, physical activity, BMI, waist circumference, and energy, the most reduced adjusted OR was indicated for the third tertile vs. the first one (OR: 0.28, 95% CI: 0.09–0.81, P = 0.02), meaning that diabetic patients in the third tertile of DTAC had 72% decreased risk of NAFLD in comparison to those in the first one. The relationship was remained significant after additional adjustment for HOMA-IR, HbA1c, serum Triglyceride (TG), and low-density lipoprotein-cholesterol (LDL) levels (OR: 0.29, 95% CI: 0.09–0.93, P = 0.03). Importantly, a dose-response pattern was demonstrated for DTAC and risk of NAFLD (P = 0.04). CONCLUSION: Higher DTAC was related with a decreased risk of NAFLD in individuals with diabetes. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9671398/ /pubmed/36407541 http://dx.doi.org/10.3389/fnut.2022.1037851 Text en Copyright © 2022 Salavatizadeh, Soltanieh, Poustchi, Yari, Shabanpur, Mansour, Khamseh, Alaei-Shahmiri and Hekmatdoost. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Salavatizadeh, Marieh
Soltanieh, Samira
Poustchi, Hossein
Yari, Zahra
Shabanpur, Maryam
Mansour, Asieh
Khamseh, Mohammad E.
Alaei-Shahmiri, Fariba
Hekmatdoost, Azita
Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
title Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
title_full Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
title_fullStr Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
title_full_unstemmed Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
title_short Dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
title_sort dietary total antioxidant capacity is inversely associated with the odds of non-alcoholic fatty liver disease in people with type-2 diabetes
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671398/
https://www.ncbi.nlm.nih.gov/pubmed/36407541
http://dx.doi.org/10.3389/fnut.2022.1037851
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