Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever

Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations in the MEFV gene encoding Pyrin cause autoinflammatory disorders, such as...

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Detalles Bibliográficos
Autores principales: Mangan, Matthew S. J., Gorki, Friederike, Krause, Karoline, Heinz, Alexander, Pankow, Anne, Ebert, Thomas, Jahn, Dieter, Hiller, Karsten, Hornung, Veit, Maurer, Marcus, Schmidt, Florian I., Gerhard, Ralf, Latz, Eicke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671422/
https://www.ncbi.nlm.nih.gov/pubmed/36342970
http://dx.doi.org/10.1371/journal.pbio.3001351

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