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Leveraging pleiotropy for joint analysis of genome-wide association studies with per trait interpretations

We introduce pleiotropic association test (PAT) for joint analysis of multiple traits using genome-wide association study (GWAS) summary statistics. The method utilizes the decomposition of phenotypic covariation into genetic and environmental components to create a likelihood ratio test statistic f...

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Detalles Bibliográficos
Autores principales:	Taraszka, Kodi, Zaitlen, Noah, Eskin, Eleazar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671458/ https://www.ncbi.nlm.nih.gov/pubmed/36342933 http://dx.doi.org/10.1371/journal.pgen.1010447

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