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Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel

Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a va...

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Autores principales: Michel, Léo, Palma, Karina, Cerda, Mauricio, Lagadec, Ronan, Mayeur, Hélène, Fuentès, Michaël, Besseau, Laurence, Martin, Patrick, Magnanou, Elodie, Blader, Patrick, Concha, Miguel L., Mazan, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671474/
https://www.ncbi.nlm.nih.gov/pubmed/36407110
http://dx.doi.org/10.3389/fcell.2022.1015074
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author Michel, Léo
Palma, Karina
Cerda, Mauricio
Lagadec, Ronan
Mayeur, Hélène
Fuentès, Michaël
Besseau, Laurence
Martin, Patrick
Magnanou, Elodie
Blader, Patrick
Concha, Miguel L.
Mazan, Sylvie
author_facet Michel, Léo
Palma, Karina
Cerda, Mauricio
Lagadec, Ronan
Mayeur, Hélène
Fuentès, Michaël
Besseau, Laurence
Martin, Patrick
Magnanou, Elodie
Blader, Patrick
Concha, Miguel L.
Mazan, Sylvie
author_sort Michel, Léo
collection PubMed
description Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts.
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spelling pubmed-96714742022-11-18 Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel Michel, Léo Palma, Karina Cerda, Mauricio Lagadec, Ronan Mayeur, Hélène Fuentès, Michaël Besseau, Laurence Martin, Patrick Magnanou, Elodie Blader, Patrick Concha, Miguel L. Mazan, Sylvie Front Cell Dev Biol Cell and Developmental Biology Habenulae asymmetries are widespread across vertebrates and analyses in zebrafish, the reference model organism for this process, have provided insight into their molecular nature, their mechanisms of formation and their important roles in the integration of environmental and internal cues with a variety of organismal adaptive responses. However, the generality of the characteristics identified in this species remains an open question, even on a relatively short evolutionary scale, in teleosts. To address this question, we have characterized the broad organization of habenulae in the Atlantic salmon and quantified the asymmetries in each of the identified subdomains. Our results show that a highly conserved partitioning into a dorsal and a ventral component is retained in the Atlantic salmon and that asymmetries are mainly observed in the former as in zebrafish. A remarkable difference is that a prominent left-restricted pax6 positive nucleus is observed in the Atlantic salmon, but undetectable in zebrafish. This nucleus is not observed outside teleosts, and harbors a complex presence/absence pattern in this group, retaining its location and cytoarchitectonic organization in an elopomorph, the European eel. These findings suggest an ancient origin and high evolvability of this trait in the taxon. Taken together, our data raise novel questions about the variability of asymmetries across teleosts and their biological significance depending on ecological contexts. Frontiers Media S.A. 2022-11-03 /pmc/articles/PMC9671474/ /pubmed/36407110 http://dx.doi.org/10.3389/fcell.2022.1015074 Text en Copyright © 2022 Michel, Palma, Cerda, Lagadec, Mayeur, Fuentès, Besseau, Martin, Magnanou, Blader, Concha and Mazan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Michel, Léo
Palma, Karina
Cerda, Mauricio
Lagadec, Ronan
Mayeur, Hélène
Fuentès, Michaël
Besseau, Laurence
Martin, Patrick
Magnanou, Elodie
Blader, Patrick
Concha, Miguel L.
Mazan, Sylvie
Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
title Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
title_full Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
title_fullStr Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
title_full_unstemmed Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
title_short Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel
title_sort diversification of habenular organization and asymmetries in teleosts: insights from the atlantic salmon and european eel
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671474/
https://www.ncbi.nlm.nih.gov/pubmed/36407110
http://dx.doi.org/10.3389/fcell.2022.1015074
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