Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease

BACKGROUND AND AIMS: The host receptor for severe acute respiratory syndrome coronavirus 2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our aim was to identify factors influencing intestinal ACE2 expression in Crohn’s disease (CD), ulcerative colitis (UC), and no...

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Detalles Bibliográficos
Autores principales: Potdar, Alka A., Dube, Shishir, Naito, Takeo, Li, Katherine, Botwin, Gregory, Haritunians, Talin, Li, Dalin, Casero, David, Yang, Shaohong, Bilsborough, Janine, Perrigoue, Jacqueline G., Denson, Lee A., Daly, Mark, Targan, Stephan R., Fleshner, Phillip, Braun, Jonathan, Kugathasan, Subra, Stappenbeck, Thaddeus S., McGovern, Dermot P.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: by the AGA Institute 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671555/
https://www.ncbi.nlm.nih.gov/pubmed/33160965
http://dx.doi.org/10.1053/j.gastro.2020.10.041

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