Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the...

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Detalles Bibliográficos
Autores principales: Aramburu, Iker Valle, Hoving, Dennis, Vernardis, Spyros I., Tin, Martha C.F., Ioannou, Marianna, Temkin, Mia I., De Vasconcelos, Nathalia M., Demichev, Vadim, Helbig, Elisa Theresa, Lippert, Lena, Stahl, Klaus, White, Matthew, Radbruch, Helena, Ihlow, Jana, Horst, David, Chiesa, Scott T., Deanfield, John E., David, Sascha, Bode, Christian, Kurth, Florian, Ralser, Markus, Papayannopoulos, Venizelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671605/
https://www.ncbi.nlm.nih.gov/pubmed/36462503
http://dx.doi.org/10.1016/j.immuni.2022.11.007

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