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Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis

BACKGROUND AND AIMS: Mean platelet volume to platelet count ratio (MPV/PC) has been found to be an independent risk factor for mortality in various diseases, including cardiovascular disease, cancer, and hemodialysis. We aimed to evaluate the association between MPV/PC and all-cause and cardiovascul...

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Autores principales: Chen, Jiasi, Zhong, Zhong, Li, Jianbo, Yu, Jianwen, Yu, Yi, Li, Bin, Mao, Haiping, Li, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671719/
https://www.ncbi.nlm.nih.gov/pubmed/36405991
http://dx.doi.org/10.1155/2022/6922809
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author Chen, Jiasi
Zhong, Zhong
Li, Jianbo
Yu, Jianwen
Yu, Yi
Li, Bin
Mao, Haiping
Li, Zhijian
author_facet Chen, Jiasi
Zhong, Zhong
Li, Jianbo
Yu, Jianwen
Yu, Yi
Li, Bin
Mao, Haiping
Li, Zhijian
author_sort Chen, Jiasi
collection PubMed
description BACKGROUND AND AIMS: Mean platelet volume to platelet count ratio (MPV/PC) has been found to be an independent risk factor for mortality in various diseases, including cardiovascular disease, cancer, and hemodialysis. We aimed to evaluate the association between MPV/PC and all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients. METHODS AND RESULTS: We conducted a retrospective cohort study at a single center and enrolled 1473 PD patients who were catheterized at our PD center from January 1, 2006, to December 31, 2013. All patients were divided into four groups according to the quartiles of baseline MPV/PC levels and followed up until December 31, 2018. A total of 453 patients died, and 221 deaths were caused by cardiovascular disease during a median follow-up time of 48.0 (21.9-82.2) months. There was a significant interaction by age of association between MPV/PC level and all-cause mortality (P = 0.009), and multivariate Cox regression analysis showed that higher MPV/PC level was related to a decreased risk of all-cause and CV mortality in PD patients aged < 60 years (HR = 0.62, 95%CI = 0.40 − 0.96, P = 0.032; HR = 0.49, 95%CI = 0.26 − 0.93, P = 0.029, respectively), rather than in patients aged ≥ 60 years (HR = 1.37, 95%CI = 0.84 − 2.22, P = 0.208; HR = 1.50, 95%CI = 0.77 − 2.92, P = 0.237, respectively). CONCLUSION: Our results indicated that low MPV/PC level was an independent risk factor for all-cause and CV mortality in PD patients aged less than 60 years.
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spelling pubmed-96717192022-11-18 Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis Chen, Jiasi Zhong, Zhong Li, Jianbo Yu, Jianwen Yu, Yi Li, Bin Mao, Haiping Li, Zhijian Mediators Inflamm Research Article BACKGROUND AND AIMS: Mean platelet volume to platelet count ratio (MPV/PC) has been found to be an independent risk factor for mortality in various diseases, including cardiovascular disease, cancer, and hemodialysis. We aimed to evaluate the association between MPV/PC and all-cause and cardiovascular (CV) mortality in peritoneal dialysis (PD) patients. METHODS AND RESULTS: We conducted a retrospective cohort study at a single center and enrolled 1473 PD patients who were catheterized at our PD center from January 1, 2006, to December 31, 2013. All patients were divided into four groups according to the quartiles of baseline MPV/PC levels and followed up until December 31, 2018. A total of 453 patients died, and 221 deaths were caused by cardiovascular disease during a median follow-up time of 48.0 (21.9-82.2) months. There was a significant interaction by age of association between MPV/PC level and all-cause mortality (P = 0.009), and multivariate Cox regression analysis showed that higher MPV/PC level was related to a decreased risk of all-cause and CV mortality in PD patients aged < 60 years (HR = 0.62, 95%CI = 0.40 − 0.96, P = 0.032; HR = 0.49, 95%CI = 0.26 − 0.93, P = 0.029, respectively), rather than in patients aged ≥ 60 years (HR = 1.37, 95%CI = 0.84 − 2.22, P = 0.208; HR = 1.50, 95%CI = 0.77 − 2.92, P = 0.237, respectively). CONCLUSION: Our results indicated that low MPV/PC level was an independent risk factor for all-cause and CV mortality in PD patients aged less than 60 years. Hindawi 2022-11-10 /pmc/articles/PMC9671719/ /pubmed/36405991 http://dx.doi.org/10.1155/2022/6922809 Text en Copyright © 2022 Jiasi Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Jiasi
Zhong, Zhong
Li, Jianbo
Yu, Jianwen
Yu, Yi
Li, Bin
Mao, Haiping
Li, Zhijian
Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis
title Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis
title_full Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis
title_fullStr Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis
title_full_unstemmed Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis
title_short Effect of Mean Platelet Volume to Platelet Count Ratio on Mortality in Peritoneal Dialysis
title_sort effect of mean platelet volume to platelet count ratio on mortality in peritoneal dialysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671719/
https://www.ncbi.nlm.nih.gov/pubmed/36405991
http://dx.doi.org/10.1155/2022/6922809
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