Cargando…

Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma

Astatine-211-parthanatine ([(211)At]PTT) is an alpha-emitting radiopharmaceutical therapeutic that targets poly(adenosine-diphosphate-ribose) polymerase 1 (PARP1) in cancer cells. High-risk neuroblastomas exhibit among the highest PARP1 expression across solid tumors. In this study, we evaluated the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Makvandi, Mehran, Samanta, Minu, Martorano, Paul, Lee, Hwan, Gitto, Sarah B., Patel, Khushbu, Groff, David, Pogoriler, Jennifer, Martinez, Daniel, Riad, Aladdin, Dabagian, Hannah, Zaleski, Michael, Taghvaee, Tara, Xu, Kuiying, Lee, Ji Youn, Hou, Catherine, Farrel, Alvin, Batra, Vandana, Carlin, Sean D., Powell, Daniel J., Mach, Robert H., Pryma, Daniel A., Maris, John M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671962/ https://www.ncbi.nlm.nih.gov/pubmed/36396952 http://dx.doi.org/10.1038/s42003-022-04209-8

Ejemplares similares

Preclinical Development of [(211)At]meta- astatobenzylguanidine ([(211)At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma
por: Batra, Vandana, et al.
Publicado: (2022)

PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response
por: Riad, Aladdin, et al.
Publicado: (2020)

Realizing Clinical Trials with Astatine-211: The Chemistry Infrastructure
por: Lindegren, Sture, et al.
Publicado: (2020)

Targeted radionuclide therapy with astatine-211: Oxidative dehalogenation of astatobenzoate conjugates
por: Teze, David, et al.
Publicado: (2017)

Simulation of the distribution of astatine-211 solution dispersion in a lab room
por: Kubo, Hitoshi, et al.
Publicado: (2021)

Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy
por: Kato, Hiroki, et al.
Publicado: (2021)

Astatine-211 based radionuclide therapy: Current clinical trial landscape
por: Albertsson, Per, et al.
Publicado: (2023)

Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and Astatine-211
por: Timperanza, Chiara, et al.
Publicado: (2023)

Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia.
por: Hauck, M. L., et al.
Publicado: (1998)

Synthesis of [(211)At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution
por: Shirakami, Yoshifumi, et al.
Publicado: (2021)

Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha-Particle Therapy via Intravenous Injection
por: Huang, Xuhao, et al.
Publicado: (2022)

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex
por: Riad, Aladdin, et al.
Publicado: (2018)

Development of an autonomous solvent extraction system to isolate astatine-211 from dissolved cyclotron bombarded bismuth targets
por: O’Hara, Matthew J., et al.
Publicado: (2019)

Targeted alpha therapy using astatine ((211)At)-labeled phenylalanine: A preclinical study in glioma bearing mice
por: Watabe, Tadashi, et al.
Publicado: (2020)

Development Of [(211)At]Astatine-Based Anti-CD123 Radioimmunotherapy For Acute Leukemias and Other CD123+ Malignancies
por: Laszlo, George S., et al.
Publicado: (2022)

Development of astatine ion beams with RILIS
por: Andreyev, A, et al.
Publicado: (2010)

α‐particle therapy for synovial sarcoma in the mouse using an astatine‐211‐labeled antibody against frizzled homolog 10
por: Li, Huizi Keiko, et al.
Publicado: (2018)

Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine
por: Aso, Ayaka, et al.
Publicado: (2023)

The electron affinity of astatine
por: Leimbach, David, et al.
Publicado: (2020)

The electron affinity of astatine
por: Leimbach, David, et al.
Publicado: (2020)

Transcriptional response of BALB/c mouse thyroids following in vivo astatine-211 exposure reveals distinct gene expression profiles
por: Rudqvist, Nils, et al.
Publicado: (2012)

TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death
por: Zeng, Chenbo, et al.
Publicado: (2019)

Determination of the electron affinity of astatine
por: Leimbach, D, et al.
Publicado: (2020)

Investigation of a tellurium-packed column for isolation of astatine-211 from irradiated bismuth targets and demonstration of a semi-automated system
por: Li, Yawen, et al.
Publicado: (2019)

Targeted α-therapy using astatine ((211)At)-labeled PSMA1, 5, and 6: a preclinical evaluation as a novel compound
por: Watabe, Tadashi, et al.
Publicado: (2022)

cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies
por: Li, Yawen, et al.
Publicado: (2018)

Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone microtumors
por: Bäck, Tom A., et al.
Publicado: (2020)

Interaction of Ligands for PET with the Dopamine D3 Receptor: In Silico and In Vitro Methods
por: Hsieh, Chia-Ju, et al.
Publicado: (2021)

Characterization of Sigma-2 Receptor—Specific Binding Sites Using [(3)H]DTG and [(125)I]RHM-4
por: Weng, Chi-Chang, et al.
Publicado: (2022)

Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 Antibody in a Preclinical Syngeneic Mouse Model of Multiple Myeloma Minimal Residual Disease
por: Gouard, Sébastien, et al.
Publicado: (2020)

New neutron-rich isotopes of astatine and bismuth
por: Burke, D G, et al.
Publicado: (1989)

Towards elucidating the radiochemistry of astatine – Behavior in chloroform
por: Aneheim, Emma, et al.
Publicado: (2019)

An expanded halogen bonding scale using astatine
por: Liu, Lu, et al.
Publicado: (2021)

Exploration of Diazaspiro Cores as Piperazine Bioisosteres in the Development of σ2 Receptor Ligands
por: Xu, Kuiying, et al.
Publicado: (2022)

Determination of the electron affinity of astatine and polonium by laser photodetachment
por: Rothe, S, et al.
Publicado: (2016)

Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine
por: Rothe, Sebastian, et al.
Publicado: (2017)

Alpha decay widths of neutron deficient Francium and Astatine isotopes
por: Hornshøj, P, et al.
Publicado: (1974)

Measurement of the first ionization potential of astatine by laser ionization spectroscopy
por: Rothe, S, et al.
Publicado: (2013)

Measurement of the first ionization potential of astatine by laser ionization spectroscopy
por: Rothe, S., et al.
Publicado: (2013)

Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and Radio‐Crosslinking
por: Denk, Christoph, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_v512gv29avg5o0jlmuna558gje