Apigenin attenuates LPS-induced neurotoxicity and cognitive impairment in mice via promoting mitochondrial fusion/mitophagy: role of SIRT3/PINK1/Parkin pathway

RATIONALE: Alteration of the NAD(+) metabolic pathway is proposed to be implicated in lipopolysaccharide (LPS)-induced neurotoxicity and mitochondrial dysfunction in neurodegenerative diseases. Apigenin, a naturally-occurring flavonoid, has been reported to maintain NAD(+) levels and to preserve var...

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Detalles Bibliográficos
Autores principales: Ahmedy, Omaima A., Abdelghany, Tarek M., El-Shamarka, Marwa E. A., Khattab, Mohamed A., El-Tanbouly, Dalia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671996/
https://www.ncbi.nlm.nih.gov/pubmed/36287214
http://dx.doi.org/10.1007/s00213-022-06262-x

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