Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway

The study aimed to investigate the potential role of lysine-specific demethylase 5A (KDM5A) in cisplatin-induced ototoxicity. The effect of the KDM5A inhibitor CPI-455 was assessed by apoptosis assay, immunofluorescence, flow cytometry, seahorse respirometry assay, and auditory brainstem response te...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Zheng, Zhiwei, Li, Wen, Tang, Dongmei, Zhao, Liping, He, Yingzi, Li, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672031/
https://www.ncbi.nlm.nih.gov/pubmed/36396833
http://dx.doi.org/10.1007/s00018-022-04565-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672031/
https://www.ncbi.nlm.nih.gov/pubmed/36396833
http://dx.doi.org/10.1007/s00018-022-04565-y

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