Cargando…

Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis

OBJECTIVE: To systematically evaluate the significance of Fusobacterium nucleatum (Fn) levels the clinicopathological impacts of cancer. METHODS: Literature from Pubmed, Embase, and Web of Science was retrieved to collect all English literatures on the correlation between Fn and cancer, and the qual...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yi, Wen, Yuting, Wang, Jiayin, Lai, Xin, Xu, Ying, Zhang, Xuanping, Zhu, Xiaoyan, Ruan, Chenglin, Huang, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672069/
https://www.ncbi.nlm.nih.gov/pubmed/36406461
http://dx.doi.org/10.3389/fmicb.2022.945463
_version_ 1784832676878876672
author Wang, Yi
Wen, Yuting
Wang, Jiayin
Lai, Xin
Xu, Ying
Zhang, Xuanping
Zhu, Xiaoyan
Ruan, Chenglin
Huang, Yao
author_facet Wang, Yi
Wen, Yuting
Wang, Jiayin
Lai, Xin
Xu, Ying
Zhang, Xuanping
Zhu, Xiaoyan
Ruan, Chenglin
Huang, Yao
author_sort Wang, Yi
collection PubMed
description OBJECTIVE: To systematically evaluate the significance of Fusobacterium nucleatum (Fn) levels the clinicopathological impacts of cancer. METHODS: Literature from Pubmed, Embase, and Web of Science was retrieved to collect all English literatures on the correlation between Fn and cancer, and the quality of literatures collected was assessed based on the Newcastle-Ottawa Quality Assessment Scale. The heterogeneity and sensitivity were detected by Stata 14.0 software, and the correlation between Fn and cancer clinicopathological as the effect variables was assessed according to the odds ratio (OR) and 95% confidence interval (CI). The forest plot was drawn. RESULTS: A total of 19 articles meeting the inclusion criteria were selected. The incidence of Fn prevalence varied considerably (range: 6.1 to 83.3%) and was greater than 10% in 13 of 19 studies. Compared with those with no/low Fn levels, the high levels of Fn was positively associated with vascular invasion, nerve invasion, depth of invasion, and distant metastasis [vascular invasion: OR = 1.66, 95%CI(1.07, 2.57), I(2) = 21.9%, fixed effect model; nerve invasion: OR = 1.36, 95%CI(1.00, 1.84), I(2) = 43.1%, fixed effect model; infiltration depth: OR = 1.94, 95%CI(1.20, 3.15), I(2) = 67.2%, random effect model; distant metastasis: OR = 1.80, 95%CI(1.23, 2.64), I(2) = 3.4%, fixed effect model]. Patients with MLH1 methylation always present a higher Fn levels than those without methylation [OR = 2.53, 95%CI(1.42, 4.53), P = 0.01, I(2) = 57.5%, random effect model]. Further, Fn was associatedwith the molecular characteristics of cancers [MSI-H Vs. MSS/MSI-low: OR = 2.92, 95%CI(1.61, 5.32), P = 0.01, I(2) = 63.2%, random effect model; High Vs. Low/Negative CIMP: OR = 2.23, 95%CI(1.64, 3.03), P = 0.01, I(2) = 64.2%, random effect model; KRAS mutation Vs. wild-type: OR = 1.24, 95%CI(1.04, 1.48), P = 0.02, I(2) = 27.0%, fixed effect model; Present Vs. Abscent BRAF mutations: OR = 1.88, 95%CI(1.44, 2.45), P = 0.01, I(2) = 24.2%, fixed effect model]. The cancer patients with high levels of Fn often have worse RFS than those with no/low Fn levels[OR = 1.14, 95%CI(0.61, 1.68), P = 0.01, I(2) = 80.7%, random effect model]. CONCLUSION: This review and meta-analysis showed that Fn could be used to predict unfavorable prognosis and function as potential prognostic biomarkers in colorectal cancer (CRC). Our data may have implications for targeting Fn to develop strategies for cancer prevention and treatment.
format Online
Article
Text
id pubmed-9672069
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-96720692022-11-19 Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis Wang, Yi Wen, Yuting Wang, Jiayin Lai, Xin Xu, Ying Zhang, Xuanping Zhu, Xiaoyan Ruan, Chenglin Huang, Yao Front Microbiol Microbiology OBJECTIVE: To systematically evaluate the significance of Fusobacterium nucleatum (Fn) levels the clinicopathological impacts of cancer. METHODS: Literature from Pubmed, Embase, and Web of Science was retrieved to collect all English literatures on the correlation between Fn and cancer, and the quality of literatures collected was assessed based on the Newcastle-Ottawa Quality Assessment Scale. The heterogeneity and sensitivity were detected by Stata 14.0 software, and the correlation between Fn and cancer clinicopathological as the effect variables was assessed according to the odds ratio (OR) and 95% confidence interval (CI). The forest plot was drawn. RESULTS: A total of 19 articles meeting the inclusion criteria were selected. The incidence of Fn prevalence varied considerably (range: 6.1 to 83.3%) and was greater than 10% in 13 of 19 studies. Compared with those with no/low Fn levels, the high levels of Fn was positively associated with vascular invasion, nerve invasion, depth of invasion, and distant metastasis [vascular invasion: OR = 1.66, 95%CI(1.07, 2.57), I(2) = 21.9%, fixed effect model; nerve invasion: OR = 1.36, 95%CI(1.00, 1.84), I(2) = 43.1%, fixed effect model; infiltration depth: OR = 1.94, 95%CI(1.20, 3.15), I(2) = 67.2%, random effect model; distant metastasis: OR = 1.80, 95%CI(1.23, 2.64), I(2) = 3.4%, fixed effect model]. Patients with MLH1 methylation always present a higher Fn levels than those without methylation [OR = 2.53, 95%CI(1.42, 4.53), P = 0.01, I(2) = 57.5%, random effect model]. Further, Fn was associatedwith the molecular characteristics of cancers [MSI-H Vs. MSS/MSI-low: OR = 2.92, 95%CI(1.61, 5.32), P = 0.01, I(2) = 63.2%, random effect model; High Vs. Low/Negative CIMP: OR = 2.23, 95%CI(1.64, 3.03), P = 0.01, I(2) = 64.2%, random effect model; KRAS mutation Vs. wild-type: OR = 1.24, 95%CI(1.04, 1.48), P = 0.02, I(2) = 27.0%, fixed effect model; Present Vs. Abscent BRAF mutations: OR = 1.88, 95%CI(1.44, 2.45), P = 0.01, I(2) = 24.2%, fixed effect model]. The cancer patients with high levels of Fn often have worse RFS than those with no/low Fn levels[OR = 1.14, 95%CI(0.61, 1.68), P = 0.01, I(2) = 80.7%, random effect model]. CONCLUSION: This review and meta-analysis showed that Fn could be used to predict unfavorable prognosis and function as potential prognostic biomarkers in colorectal cancer (CRC). Our data may have implications for targeting Fn to develop strategies for cancer prevention and treatment. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9672069/ /pubmed/36406461 http://dx.doi.org/10.3389/fmicb.2022.945463 Text en Copyright © 2022 Wang, Wen, Wang, Lai, Xu, Zhang, Zhu, Ruan and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Yi
Wen, Yuting
Wang, Jiayin
Lai, Xin
Xu, Ying
Zhang, Xuanping
Zhu, Xiaoyan
Ruan, Chenglin
Huang, Yao
Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
title Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
title_full Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
title_fullStr Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
title_full_unstemmed Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
title_short Clinicopathological differences of high Fusobacterium nucleatum levels in colorectal cancer: A review and meta-analysis
title_sort clinicopathological differences of high fusobacterium nucleatum levels in colorectal cancer: a review and meta-analysis
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672069/
https://www.ncbi.nlm.nih.gov/pubmed/36406461
http://dx.doi.org/10.3389/fmicb.2022.945463
work_keys_str_mv AT wangyi clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT wenyuting clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT wangjiayin clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT laixin clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT xuying clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT zhangxuanping clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT zhuxiaoyan clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT ruanchenglin clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis
AT huangyao clinicopathologicaldifferencesofhighfusobacteriumnucleatumlevelsincolorectalcancerareviewandmetaanalysis