Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

Histone acetylation/deacetylation play an essential role in modifying chromatin structure and in regulating cell plasticity in eukaryotic cells. Therefore, histone deacetylase (HDAC) pharmacological inhibitors are promising tools in the therapy of fibrotic diseases and in cancer. Peritoneal fibrosis...

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Detalles Bibliográficos
Autores principales: Bontempi, Giulio, Terri, Michela, Garbo, Sabrina, Montaldo, Claudia, Mariotti, Davide, Bordoni, Veronica, Valente, Sergio, Zwergel, Clemens, Mai, Antonello, Marchetti, Alessandra, Domenici, Alessandro, Menè, Paolo, Battistelli, Cecilia, Tripodi, Marco, Strippoli, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672101/
https://www.ncbi.nlm.nih.gov/pubmed/36396626
http://dx.doi.org/10.1038/s41419-022-05398-0

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