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Development of the stria vascularis in the common marmoset, a primate model
Stria vascularis is a structure that generates potassium gradients in the cochlea, which is vital for hair cells to convert mechanical sound waves into electrical pulses. The precise development of the stria vascularis and subsequent generation of endocochlear potential are thus essential for hearin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672111/ https://www.ncbi.nlm.nih.gov/pubmed/36396805 http://dx.doi.org/10.1038/s41598-022-24380-6 |
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author | Hosoya, Makoto Kitama, Tsubasa Iwabu, Kaho Nishiyama, Takanori Oishi, Naoki Okano, Hideyuki Ozawa, Hiroyuki |
author_facet | Hosoya, Makoto Kitama, Tsubasa Iwabu, Kaho Nishiyama, Takanori Oishi, Naoki Okano, Hideyuki Ozawa, Hiroyuki |
author_sort | Hosoya, Makoto |
collection | PubMed |
description | Stria vascularis is a structure that generates potassium gradients in the cochlea, which is vital for hair cells to convert mechanical sound waves into electrical pulses. The precise development of the stria vascularis and subsequent generation of endocochlear potential are thus essential for hearing. Understanding the development of the stria vascularis is valuable for studying hearing loss caused by aging or genetics and designing regenerative therapy. Although inter-species differences have been reported between rodents and humans, most of our current knowledge regarding cochlear development has been obtained from rodent models because of the difficulty in using human fetal samples in this field of research. Therefore, we investigated the development of the cochlear stria vascularis in the common marmoset (Callithrix jacchus), a small monkey species native to the New World. Our study confirms that stria vascularis development in the common marmoset is similar to that in humans and is suitable for furthering our understanding of human cochlear development. The time course established in this report will aid in studying the primate-specific developmental biology of the inner ear, which could eventually lead to new treatment strategies for hearing loss in humans. |
format | Online Article Text |
id | pubmed-9672111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-96721112022-11-19 Development of the stria vascularis in the common marmoset, a primate model Hosoya, Makoto Kitama, Tsubasa Iwabu, Kaho Nishiyama, Takanori Oishi, Naoki Okano, Hideyuki Ozawa, Hiroyuki Sci Rep Article Stria vascularis is a structure that generates potassium gradients in the cochlea, which is vital for hair cells to convert mechanical sound waves into electrical pulses. The precise development of the stria vascularis and subsequent generation of endocochlear potential are thus essential for hearing. Understanding the development of the stria vascularis is valuable for studying hearing loss caused by aging or genetics and designing regenerative therapy. Although inter-species differences have been reported between rodents and humans, most of our current knowledge regarding cochlear development has been obtained from rodent models because of the difficulty in using human fetal samples in this field of research. Therefore, we investigated the development of the cochlear stria vascularis in the common marmoset (Callithrix jacchus), a small monkey species native to the New World. Our study confirms that stria vascularis development in the common marmoset is similar to that in humans and is suitable for furthering our understanding of human cochlear development. The time course established in this report will aid in studying the primate-specific developmental biology of the inner ear, which could eventually lead to new treatment strategies for hearing loss in humans. Nature Publishing Group UK 2022-11-17 /pmc/articles/PMC9672111/ /pubmed/36396805 http://dx.doi.org/10.1038/s41598-022-24380-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hosoya, Makoto Kitama, Tsubasa Iwabu, Kaho Nishiyama, Takanori Oishi, Naoki Okano, Hideyuki Ozawa, Hiroyuki Development of the stria vascularis in the common marmoset, a primate model |
title | Development of the stria vascularis in the common marmoset, a primate model |
title_full | Development of the stria vascularis in the common marmoset, a primate model |
title_fullStr | Development of the stria vascularis in the common marmoset, a primate model |
title_full_unstemmed | Development of the stria vascularis in the common marmoset, a primate model |
title_short | Development of the stria vascularis in the common marmoset, a primate model |
title_sort | development of the stria vascularis in the common marmoset, a primate model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672111/ https://www.ncbi.nlm.nih.gov/pubmed/36396805 http://dx.doi.org/10.1038/s41598-022-24380-6 |
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