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Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials
The back-propagating action potential (bpAP) is crucial for neuronal signal integration and synaptic plasticity in dendritic trees. Its properties (velocity and amplitude) can be affected by dendritic morphology. Due to limited spatial resolution, it has been difficult to explore the specific propag...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672184/ https://www.ncbi.nlm.nih.gov/pubmed/35984622 http://dx.doi.org/10.1007/s12264-022-00931-9 |
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author | Tian, Wu Peng, Luxin Zhao, Mengdi Tao, Louis Zou, Peng Zhang, Yan |
author_facet | Tian, Wu Peng, Luxin Zhao, Mengdi Tao, Louis Zou, Peng Zhang, Yan |
author_sort | Tian, Wu |
collection | PubMed |
description | The back-propagating action potential (bpAP) is crucial for neuronal signal integration and synaptic plasticity in dendritic trees. Its properties (velocity and amplitude) can be affected by dendritic morphology. Due to limited spatial resolution, it has been difficult to explore the specific propagation process of bpAPs along dendrites and examine the influence of dendritic morphology, such as the dendrite diameter and branching pattern, using patch-clamp recording. By taking advantage of Optopatch, an all-optical electrophysiological method, we made detailed recordings of the real-time propagation of bpAPs in dendritic trees. We found that the velocity of bpAPs was not uniform in a single dendrite, and the bpAP velocity differed among distinct dendrites of the same neuron. The velocity of a bpAP was positively correlated with the diameter of the dendrite on which it propagated. In addition, when bpAPs passed through a dendritic branch point, their velocity decreased significantly. Similar to velocity, the amplitude of bpAPs was also positively correlated with dendritic diameter, and the attenuation patterns of bpAPs differed among different dendrites. Simulation results from neuron models with different dendritic morphology corresponded well with the experimental results. These findings indicate that the dendritic diameter and branching pattern significantly influence the properties of bpAPs. The diversity among the bpAPs recorded in different neurons was mainly due to differences in dendritic morphology. These results may inspire the construction of neuronal models to predict the propagation of bpAPs in dendrites with enormous variation in morphology, to further illuminate the role of bpAPs in neuronal communication. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-022-00931-9. |
format | Online Article Text |
id | pubmed-9672184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-96721842022-11-19 Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials Tian, Wu Peng, Luxin Zhao, Mengdi Tao, Louis Zou, Peng Zhang, Yan Neurosci Bull Original Article The back-propagating action potential (bpAP) is crucial for neuronal signal integration and synaptic plasticity in dendritic trees. Its properties (velocity and amplitude) can be affected by dendritic morphology. Due to limited spatial resolution, it has been difficult to explore the specific propagation process of bpAPs along dendrites and examine the influence of dendritic morphology, such as the dendrite diameter and branching pattern, using patch-clamp recording. By taking advantage of Optopatch, an all-optical electrophysiological method, we made detailed recordings of the real-time propagation of bpAPs in dendritic trees. We found that the velocity of bpAPs was not uniform in a single dendrite, and the bpAP velocity differed among distinct dendrites of the same neuron. The velocity of a bpAP was positively correlated with the diameter of the dendrite on which it propagated. In addition, when bpAPs passed through a dendritic branch point, their velocity decreased significantly. Similar to velocity, the amplitude of bpAPs was also positively correlated with dendritic diameter, and the attenuation patterns of bpAPs differed among different dendrites. Simulation results from neuron models with different dendritic morphology corresponded well with the experimental results. These findings indicate that the dendritic diameter and branching pattern significantly influence the properties of bpAPs. The diversity among the bpAPs recorded in different neurons was mainly due to differences in dendritic morphology. These results may inspire the construction of neuronal models to predict the propagation of bpAPs in dendrites with enormous variation in morphology, to further illuminate the role of bpAPs in neuronal communication. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12264-022-00931-9. Springer Nature Singapore 2022-08-19 /pmc/articles/PMC9672184/ /pubmed/35984622 http://dx.doi.org/10.1007/s12264-022-00931-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Tian, Wu Peng, Luxin Zhao, Mengdi Tao, Louis Zou, Peng Zhang, Yan Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials |
title | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials |
title_full | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials |
title_fullStr | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials |
title_full_unstemmed | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials |
title_short | Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials |
title_sort | dendritic morphology affects the velocity and amplitude of back-propagating action potentials |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672184/ https://www.ncbi.nlm.nih.gov/pubmed/35984622 http://dx.doi.org/10.1007/s12264-022-00931-9 |
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