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Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma

This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data of 119 patients who received radiotherapy at our department from 1997 to 2014 for intracranial WHO grade...

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Autores principales: Lisowski, Dominik, Trömel, Jannik, Lutyj, Paul, Lewitzki, Victor, Hartrampf, Philipp E., Polat, Bülent, Flentje, Michael, Tamihardja, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672325/
https://www.ncbi.nlm.nih.gov/pubmed/36396802
http://dx.doi.org/10.1038/s41598-022-24192-8
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author Lisowski, Dominik
Trömel, Jannik
Lutyj, Paul
Lewitzki, Victor
Hartrampf, Philipp E.
Polat, Bülent
Flentje, Michael
Tamihardja, Jörg
author_facet Lisowski, Dominik
Trömel, Jannik
Lutyj, Paul
Lewitzki, Victor
Hartrampf, Philipp E.
Polat, Bülent
Flentje, Michael
Tamihardja, Jörg
author_sort Lisowski, Dominik
collection PubMed
description This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data of 119 patients who received radiotherapy at our department from 1997 to 2014 for intracranial WHO grade I-III meningioma. Fractionated stereotactic radiotherapy (FSRT), intensity modulated radiotherapy (IMRT) or radiosurgery radiation was applied. The EORTC QLQ-C30 and QLQ-BN20 questionnaires were completed for assessment of HRQoL. Overall survival (OS) for the entire study group was 89.6% at 5 years and 75.9% at 10 years. Local control (LC) at 5 and 10 years was 82.4% and 73.4%, respectively. Local recurrence was observed in 22 patients (18.5%). Higher grade acute and chronic toxicities were observed in seven patients (5.9%) and five patients (4.2%), respectively. Global health status was rated with a mean of 59.9 points (SD 22.3) on QLQ-C30. In conclusion, radiotherapy resulted in very good long-term survival and tumor control rates with low rates of severe toxicities but with a deterioration of long-term HRQoL.
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spelling pubmed-96723252022-11-19 Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma Lisowski, Dominik Trömel, Jannik Lutyj, Paul Lewitzki, Victor Hartrampf, Philipp E. Polat, Bülent Flentje, Michael Tamihardja, Jörg Sci Rep Article This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data of 119 patients who received radiotherapy at our department from 1997 to 2014 for intracranial WHO grade I-III meningioma. Fractionated stereotactic radiotherapy (FSRT), intensity modulated radiotherapy (IMRT) or radiosurgery radiation was applied. The EORTC QLQ-C30 and QLQ-BN20 questionnaires were completed for assessment of HRQoL. Overall survival (OS) for the entire study group was 89.6% at 5 years and 75.9% at 10 years. Local control (LC) at 5 and 10 years was 82.4% and 73.4%, respectively. Local recurrence was observed in 22 patients (18.5%). Higher grade acute and chronic toxicities were observed in seven patients (5.9%) and five patients (4.2%), respectively. Global health status was rated with a mean of 59.9 points (SD 22.3) on QLQ-C30. In conclusion, radiotherapy resulted in very good long-term survival and tumor control rates with low rates of severe toxicities but with a deterioration of long-term HRQoL. Nature Publishing Group UK 2022-11-17 /pmc/articles/PMC9672325/ /pubmed/36396802 http://dx.doi.org/10.1038/s41598-022-24192-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lisowski, Dominik
Trömel, Jannik
Lutyj, Paul
Lewitzki, Victor
Hartrampf, Philipp E.
Polat, Bülent
Flentje, Michael
Tamihardja, Jörg
Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
title Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
title_full Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
title_fullStr Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
title_full_unstemmed Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
title_short Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
title_sort health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672325/
https://www.ncbi.nlm.nih.gov/pubmed/36396802
http://dx.doi.org/10.1038/s41598-022-24192-8
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