Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish

Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. However, the pathogenesis remains largely unknown. There are two homologous genes of TULP1 in zebrafish, namely tulp1a and tulp1b. Here, we generated the single knockout (tulp1a(−/−) and tu...

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Detalles Bibliográficos
Autores principales: Jia, Danna, Gao, Pan, Lv, Yuexia, Huang, Yuwen, Reilly, James, Sun, Kui, Han, Yunqiao, Hu, Hualei, Chen, Xiang, Zhang, Zuxiao, Li, Pei, Luo, Jiong, Shu, Xinhua, Tang, Zhaohui, Liu, Fei, Liu, Mugen, Ren, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672332/
https://www.ncbi.nlm.nih.gov/pubmed/36396940
http://dx.doi.org/10.1038/s41419-022-05372-w

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