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Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm

BACKGROUND: Solid pseudopapillary neoplasm (SPN) is a rare tumor with low malignant potential, which typically occurs in the pancreas. Extrapancreatic SPN is also extremely rare worldwide. CASE PRESENTATION: We report a case of a 70-year-old woman hospitalized with abdominal pain and bloating. The p...

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Autores principales: Liu, Hang, Xu, Zhiquan, Wang, Yaxu, Gu, Haitao, Tang, Yunhao, Wu, Dabin, Wang, Jijian, Zhang, Jianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672344/
https://www.ncbi.nlm.nih.gov/pubmed/36406380
http://dx.doi.org/10.3389/fsurg.2022.1020044
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author Liu, Hang
Xu, Zhiquan
Wang, Yaxu
Gu, Haitao
Tang, Yunhao
Wu, Dabin
Wang, Jijian
Zhang, Jianbo
author_facet Liu, Hang
Xu, Zhiquan
Wang, Yaxu
Gu, Haitao
Tang, Yunhao
Wu, Dabin
Wang, Jijian
Zhang, Jianbo
author_sort Liu, Hang
collection PubMed
description BACKGROUND: Solid pseudopapillary neoplasm (SPN) is a rare tumor with low malignant potential, which typically occurs in the pancreas. Extrapancreatic SPN is also extremely rare worldwide. CASE PRESENTATION: We report a case of a 70-year-old woman hospitalized with abdominal pain and bloating. The patient did not have any underlying diseases, such as diabetes, coronary heart disease, or hypertension. More than 30 years ago, the patient underwent surgery for “ectopic pregnancy”. The patient had no family history of hereditary disease, nor did any immediate family members have a history of cancer. Laboratory tests showed that her hemoglobin and albumin levels were low and she had a high level of cancer antigen 125 (CA125). Enhanced computed tomography (CT) showed a large tumor in the abdomen and pelvis. The patient subsequently underwent surgery, and it was found that the tumor was attached to the terminal ileum. Pathological findings suggested that the tumor was an extrapancreatic SPN, with an ectopic pancreas found in the tumor tissue. The patient did not receive chemotherapy or radiotherapy after surgery. After 13 months of follow-up, the patient was admitted again with abdominal pain. CT showed tumor recurrence with extensive systemic metastases. The patient and her family refused reoperation and biopsy, and the patient was discharged after the abdominal pain and anemia resolved. CONCLUSION: We report a rare case of extrapancreatic SPN of ileal origin, which could be the first report worldwide. It had aggressive biological features, with recurrence and metastasis 13 months after surgery. For extrapancreatic SPN, the risk of recurrence should be assessed, and for tumors suspected of malignant behavior, a longer follow-up after discharge may be needed. Although SPN generally has a good prognosis after surgery, there is no consensus on whether postoperative chemotherapy and other treatments are needed for patients with high recurrence risk.
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spelling pubmed-96723442022-11-19 Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm Liu, Hang Xu, Zhiquan Wang, Yaxu Gu, Haitao Tang, Yunhao Wu, Dabin Wang, Jijian Zhang, Jianbo Front Surg Surgery BACKGROUND: Solid pseudopapillary neoplasm (SPN) is a rare tumor with low malignant potential, which typically occurs in the pancreas. Extrapancreatic SPN is also extremely rare worldwide. CASE PRESENTATION: We report a case of a 70-year-old woman hospitalized with abdominal pain and bloating. The patient did not have any underlying diseases, such as diabetes, coronary heart disease, or hypertension. More than 30 years ago, the patient underwent surgery for “ectopic pregnancy”. The patient had no family history of hereditary disease, nor did any immediate family members have a history of cancer. Laboratory tests showed that her hemoglobin and albumin levels were low and she had a high level of cancer antigen 125 (CA125). Enhanced computed tomography (CT) showed a large tumor in the abdomen and pelvis. The patient subsequently underwent surgery, and it was found that the tumor was attached to the terminal ileum. Pathological findings suggested that the tumor was an extrapancreatic SPN, with an ectopic pancreas found in the tumor tissue. The patient did not receive chemotherapy or radiotherapy after surgery. After 13 months of follow-up, the patient was admitted again with abdominal pain. CT showed tumor recurrence with extensive systemic metastases. The patient and her family refused reoperation and biopsy, and the patient was discharged after the abdominal pain and anemia resolved. CONCLUSION: We report a rare case of extrapancreatic SPN of ileal origin, which could be the first report worldwide. It had aggressive biological features, with recurrence and metastasis 13 months after surgery. For extrapancreatic SPN, the risk of recurrence should be assessed, and for tumors suspected of malignant behavior, a longer follow-up after discharge may be needed. Although SPN generally has a good prognosis after surgery, there is no consensus on whether postoperative chemotherapy and other treatments are needed for patients with high recurrence risk. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9672344/ /pubmed/36406380 http://dx.doi.org/10.3389/fsurg.2022.1020044 Text en © 2022 Liu, Xu, Wang, Gu, Tang, Wu, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Liu, Hang
Xu, Zhiquan
Wang, Yaxu
Gu, Haitao
Tang, Yunhao
Wu, Dabin
Wang, Jijian
Zhang, Jianbo
Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm
title Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm
title_full Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm
title_fullStr Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm
title_full_unstemmed Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm
title_short Case report: A case report and literature review of extrapancreatic solid pseudopapillary neoplasm
title_sort case report: a case report and literature review of extrapancreatic solid pseudopapillary neoplasm
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672344/
https://www.ncbi.nlm.nih.gov/pubmed/36406380
http://dx.doi.org/10.3389/fsurg.2022.1020044
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