CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids

Mutations in CHD7 cause CHARGE syndrome, affecting multiple organs including the inner ear in humans. We investigate how CHD7 mutations affect inner ear development using human pluripotent stem cell-derived organoids as a model system. We find that loss of CHD7 or its chromatin remodeling activity l...

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Detalles Bibliográficos
Autores principales: Nie, Jing, Ueda, Yoshitomo, Solivais, Alexander J., Hashino, Eri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672366/
https://www.ncbi.nlm.nih.gov/pubmed/36396635
http://dx.doi.org/10.1038/s41467-022-34759-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672366/
https://www.ncbi.nlm.nih.gov/pubmed/36396635
http://dx.doi.org/10.1038/s41467-022-34759-8

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