Cargando…
Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treat...
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672394/ https://www.ncbi.nlm.nih.gov/pubmed/36396935 http://dx.doi.org/10.1038/s41467-022-34776-7 |
| _version_ | 1784832724132954112 |
|---|---|
| author | Romitti, Mírian Tourneur, Adrien de Faria da Fonseca, Barbara Doumont, Gilles Gillotay, Pierre Liao, Xiao-Hui Eski, Sema Elif Van Simaeys, Gaetan Chomette, Laura Lasolle, Helene Monestier, Olivier Kasprzyk, Dominika Figini Detours, Vincent Singh, Sumeet Pal Goldman, Serge Refetoff, Samuel Costagliola, Sabine |
| author_facet | Romitti, Mírian Tourneur, Adrien de Faria da Fonseca, Barbara Doumont, Gilles Gillotay, Pierre Liao, Xiao-Hui Eski, Sema Elif Van Simaeys, Gaetan Chomette, Laura Lasolle, Helene Monestier, Olivier Kasprzyk, Dominika Figini Detours, Vincent Singh, Sumeet Pal Goldman, Serge Refetoff, Samuel Costagliola, Sabine |
| author_sort | Romitti, Mírian |
| collection | PubMed |
| description | The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development. |
| format | Online Article Text |
| id | pubmed-9672394 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-96723942022-11-19 Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism Romitti, Mírian Tourneur, Adrien de Faria da Fonseca, Barbara Doumont, Gilles Gillotay, Pierre Liao, Xiao-Hui Eski, Sema Elif Van Simaeys, Gaetan Chomette, Laura Lasolle, Helene Monestier, Olivier Kasprzyk, Dominika Figini Detours, Vincent Singh, Sumeet Pal Goldman, Serge Refetoff, Samuel Costagliola, Sabine Nat Commun Article The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development. Nature Publishing Group UK 2022-11-17 /pmc/articles/PMC9672394/ /pubmed/36396935 http://dx.doi.org/10.1038/s41467-022-34776-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Romitti, Mírian Tourneur, Adrien de Faria da Fonseca, Barbara Doumont, Gilles Gillotay, Pierre Liao, Xiao-Hui Eski, Sema Elif Van Simaeys, Gaetan Chomette, Laura Lasolle, Helene Monestier, Olivier Kasprzyk, Dominika Figini Detours, Vincent Singh, Sumeet Pal Goldman, Serge Refetoff, Samuel Costagliola, Sabine Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| title | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| title_full | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| title_fullStr | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| title_full_unstemmed | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| title_short | Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| title_sort | transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672394/ https://www.ncbi.nlm.nih.gov/pubmed/36396935 http://dx.doi.org/10.1038/s41467-022-34776-7 |
| work_keys_str_mv | AT romittimirian transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT tourneuradrien transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT defariadafonsecabarbara transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT doumontgilles transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT gillotaypierre transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT liaoxiaohui transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT eskisemaelif transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT vansimaeysgaetan transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT chomettelaura transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT lasollehelene transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT monestierolivier transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT kasprzykdominikafigini transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT detoursvincent transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT singhsumeetpal transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT goldmanserge transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT refetoffsamuel transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism AT costagliolasabine transplantablehumanthyroidorganoidsgeneratedfromembryonicstemcellstorescuehypothyroidism |