Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis

MqnA, the only chorismate dehydratase known so far, catalyzes the initial step in the biosynthesis of menaquinone via the futalosine pathway. Details of the MqnA reaction mechanism remain unclear. Here, we present crystal structures of Streptomyces coelicolor MqnA and its active site mutants in comp...

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Detalles Bibliográficos
Autores principales: Prasad, Archna, Breithaupt, Constanze, Nguyen, Duc-Anh, Lilie, Hauke, Ziegler, Jörg, Stubbs, Milton T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672406/
https://www.ncbi.nlm.nih.gov/pubmed/36265588
http://dx.doi.org/10.1016/j.jbc.2022.102601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672406/
https://www.ncbi.nlm.nih.gov/pubmed/36265588
http://dx.doi.org/10.1016/j.jbc.2022.102601

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