Cargando…

Mechanism of chorismate dehydratase MqnA, the first enzyme of the futalosine pathway, proceeds via substrate-assisted catalysis

MqnA, the only chorismate dehydratase known so far, catalyzes the initial step in the biosynthesis of menaquinone via the futalosine pathway. Details of the MqnA reaction mechanism remain unclear. Here, we present crystal structures of Streptomyces coelicolor MqnA and its active site mutants in comp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prasad, Archna, Breithaupt, Constanze, Nguyen, Duc-Anh, Lilie, Hauke, Ziegler, Jörg, Stubbs, Milton T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672406/ https://www.ncbi.nlm.nih.gov/pubmed/36265588 http://dx.doi.org/10.1016/j.jbc.2022.102601

Ejemplares similares

Putative Bifunctional Chorismate Mutase/Prephenate Dehydratase Contributes to the Virulence of Acidovorax citrulli
por: Kim, Minyoung, et al.
Publicado: (2020)

Novel exported fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: Shikimate pathway enzymes teamed up in no man's land
por: Stocker, Christian, et al.
Publicado: (2023)

Bacterial bifunctional chorismate mutase-prephenate dehydratase PheA increases flux into the yeast phenylalanine pathway and improves mandelic acid production
por: Reifenrath, Mara, et al.
Publicado: (2018)

The Futalosine Pathway Played an Important Role in Menaquinone Biosynthesis during Early Prokaryote Evolution
por: Zhi, Xiao-Yang, et al.
Publicado: (2014)

New function of aldoxime dehydratase: Redox catalysis and the formation of an expected product
por: Yamada, Masatoshi, et al.
Publicado: (2017)

Correction: New function of aldoxime dehydratase: Redox catalysis and the formation of an expected product
por: Yamada, Masatoshi, et al.
Publicado: (2017)

The importance of chorismate mutase in the biocontrol potential of Trichoderma parareesei
por: Pérez, Esclaudys, et al.
Publicado: (2015)

Review on Abyssomicins: Inhibitors of the Chorismate Pathway and Folate Biosynthesis
por: Sadaka, Carmen, et al.
Publicado: (2018)

Revisiting the dual pathway hypothesis of Chorismate production in plants
por: Lynch, Joseph H
Publicado: (2022)

Quantum chemical modeling of the reaction path of chorismate mutase based on the experimental substrate/product complex
por: Burschowsky, Daniel, et al.
Publicado: (2017)

Completion of the cytosolic post-chorismate phenylalanine biosynthetic pathway in plants
por: Qian, Yichun, et al.
Publicado: (2019)

Chorismate mutase peptide antibody enables specific detection of Acanthamoeba
por: Lee, Hae-Ahm, et al.
Publicado: (2021)

Novel isatin–indole derivatives as potential inhibitors of chorismate mutase (CM): their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd–Cu catalysis
por: Reddy, Gangireddy Sujeevan, et al.
Publicado: (2020)

Comprehensive database of Chorismate synthase enzyme from shikimate pathway in pathogenic bacteria
por: Pitchandi, Prabakaran, et al.
Publicado: (2013)

Rational Engineering of Chorismate-Related Pathways in Saccharomyces cerevisiae for Improving Tyrosol Production
por: Guo, Wei, et al.
Publicado: (2019)

Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance
por: Fahrig-Kamarauskait≑, Jūrate˙, et al.
Publicado: (2020)

CRISPR-Driven Genome Engineering for Chorismate- and Anthranilate-Accumulating Corynebacterium Cell Factories
por: Kim, Hye-Jin, et al.
Publicado: (2023)

Structural insights into dehydratase substrate selection for the borrelidin and fluvirucin polyketide synthases
por: Barajas, Jesus F., et al.
Publicado: (2019)

Nucleotide sugar dehydratases: Structure, mechanism, substrate specificity, and application potential
por: Vogel, Ulrike, et al.
Publicado: (2022)

Discovery of Function in the Enolase Superfamily: d-Mannonate and d-Gluconate Dehydratases in the d-Mannonate Dehydratase Subgroup
por: Wichelecki, Daniel J., et al.
Publicado: (2014)

Molecular Evolution of Threonine Dehydratase in Bacteria
por: Yu, Xuefei, et al.
Publicado: (2013)

Cscs encoding chorismate synthase is a candidate gene for leaf variegation mutation in cucumber
por: Cao, Wen, et al.
Publicado: (2018)

Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor
por: Valenciano, Ana Lisa, et al.
Publicado: (2019)

The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2018)

Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate
por: Schäfer, Martin, et al.
Publicado: (2016)

The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase
por: Ely, Fernanda, et al.
Publicado: (2008)

Horizontal gene transfer of acetyltransferases, invertases and chorismate mutases from different bacteria to diverse recipients
por: Noon, Jason B., et al.
Publicado: (2016)

High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB
por: Zhao, Xinghong, et al.
Publicado: (2020)

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid-dependent autophagy response in parasite
por: Chakrabarti, Malabika, et al.
Publicado: (2020)

What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study
por: Thorbjørnsrud, Helen V., et al.
Publicado: (2023)

Evaluating the Diagnostic Potential of Chorismate Mutase Poly-Clonal Peptide Antibody for the Acanthamoeba Keratitis in an Animal Model
por: Kim, Min-Jeong, et al.
Publicado: (2023)

Structural Insight into Substrate Specificity of 3-Hydroxypropionyl-Coenzyme A Dehydratase from Metallosphaera sedula
por: Lee, Donghoon, et al.
Publicado: (2018)

Discovery of Selective Inhibitors of the Clostridium difficile Dehydroquinate Dehydratase
por: Ratia, Kiira, et al.
Publicado: (2014)

The Role of ACT-Like Subdomain in Bacterial Threonine Dehydratases
por: Yu, Xuefei, et al.
Publicado: (2014)

Silencing of Vlaro2 for chorismate synthase revealed that the phytopathogen Verticillium longisporum induces the cross-pathway control in the xylem
por: Singh, Seema, et al.
Publicado: (2009)

Suppression of chorismate synthase, which is localized in chloroplasts and peroxisomes, results in abnormal flower development and anthocyanin reduction in petunia
por: Zhong, Shiwei, et al.
Publicado: (2020)

A Secreted Chorismate Mutase from Xanthomonas arboricola pv. juglandis Attenuates Virulence and Walnut Blight Symptoms
por: Assis, Renata de A. B., et al.
Publicado: (2021)

The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases
por: Dillon, Shane C, et al.
Publicado: (2004)

Crystallization and X-ray diffraction analysis of an l-arabinonate dehydratase from Rhizobium leguminosarum bv. trifolii and a d-xylonate dehydratase from Caulobacter crescentus
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2016)

The emerging periplasm-localized subclass of AroQ chorismate mutases, exemplified by those from Salmonella typhimurium and Pseudomonas aeruginosa
por: Calhoun, David H, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_t5kt0jm37dcjer0rj3fo7k6b1f