A mutated glycosaminoglycan-binding domain functions as a novel probe to selectively target heparin-like epitopes on tumor cells

The high heterogeneity and mutation rate of cancer cells often lead to the failure of targeted therapy, and therefore, new targets for multitarget therapy of tumors are urgently needed. Aberrantly expressed glycosaminoglycans (GAGs) have been shown to be involved in tumorigenesis and are promising n...

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Detalles Bibliográficos
Autores principales: Xu, Yingying, Shi, Liran, Qin, Yong, Yuan, Xunyi, Wang, Xu, Zhang, Qingdong, Wei, Lin, Du, Min, Liu, Yi, Yuan, Min, Xu, Xiangyu, Cheng, Ruiqing, Zou, Ruyi, Wang, Wenshuang, Li, Fuchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672413/
https://www.ncbi.nlm.nih.gov/pubmed/36265583
http://dx.doi.org/10.1016/j.jbc.2022.102609

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