Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

OBJECTIVE: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT8 might play a role beyond simply being a target o...

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Detalles Bibliográficos
Autores principales: Kim, Yong Kyung, Walters, Jay A., Moss, Nicole D., Wells, Kristen L., Sheridan, Ryan, Miranda, Jose G., Benninger, Richard K.P., Pyle, Laura L., O'Brien, Richard M., Sussel, Lori, Davidson, Howard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672421/
https://www.ncbi.nlm.nih.gov/pubmed/36347424
http://dx.doi.org/10.1016/j.molmet.2022.101632

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