GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells

BACKGROUND & AIMS: In contrast to mismatch repair deficient colorectal carcinoma (CRC), MMR proficient (pMMR) CRC does not respond to immune checkpoint blockade. We studied immune checkpoint stimulation via glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) on ex vivo f...

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Detalles Bibliográficos
Autores principales: Rakké, Yannick S., Campos Carrascosa, Lucia, van Beek, Adriaan A., de Ruiter, Valeska, van Gemerden, Rachelle S., Doukas, Michail, Doornebosch, Pascal G., Vermaas, Maarten, ter Borg, Susan, van der Harst, Erwin, Coene, Peter Paul L.O., Kliffen, Mike, Grünhagen, Dirk J., Verhoef, Cornelis, IJzermans, Jan N.M., Kwekkeboom, Jaap, Sprengers, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672455/
https://www.ncbi.nlm.nih.gov/pubmed/36155259
http://dx.doi.org/10.1016/j.jcmgh.2022.09.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672455/
https://www.ncbi.nlm.nih.gov/pubmed/36155259
http://dx.doi.org/10.1016/j.jcmgh.2022.09.007

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