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Researches on cognitive sequelae of burn injury: Current status and advances
Burn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary periphera...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672468/ https://www.ncbi.nlm.nih.gov/pubmed/36408414 http://dx.doi.org/10.3389/fnins.2022.1026152 |
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author | Xie, Chenchen Hu, Jun Cheng, Yong Yao, Zhongxiang |
author_facet | Xie, Chenchen Hu, Jun Cheng, Yong Yao, Zhongxiang |
author_sort | Xie, Chenchen |
collection | PubMed |
description | Burn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary peripheral factors and the secondary cerebral inflammation, resulting in the destruction of blood-brain barrier (BBB), as is shown on Computed Tomography (CT) and magnetic resonance imaging examinations. As part of the neurovascular unit, BBB is vital to the nutrition and homeostasis of the central nervous system (CNS) and undergoes myriad alterations after burn injury, causing post-burn cognitive defects. The diagnosis and treatment of cognitive dysfunctions as burn injury sequelae are of great importance. In this review, we address the major manifestations and interventions of post-burn cognitive defects, as well as the mechanisms involved in memory defect, including neuroinflammation, destruction of BBB, and hormone imbalance. |
format | Online Article Text |
id | pubmed-9672468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96724682022-11-19 Researches on cognitive sequelae of burn injury: Current status and advances Xie, Chenchen Hu, Jun Cheng, Yong Yao, Zhongxiang Front Neurosci Neuroscience Burn injury is a devastating disease with high incidence of disability and mortality. The cognitive dysfunctions, such as memory defect, are the main neurological sequelae influencing the life quality of burn-injured patients. The post-burn cognitive dysfunctions are related to the primary peripheral factors and the secondary cerebral inflammation, resulting in the destruction of blood-brain barrier (BBB), as is shown on Computed Tomography (CT) and magnetic resonance imaging examinations. As part of the neurovascular unit, BBB is vital to the nutrition and homeostasis of the central nervous system (CNS) and undergoes myriad alterations after burn injury, causing post-burn cognitive defects. The diagnosis and treatment of cognitive dysfunctions as burn injury sequelae are of great importance. In this review, we address the major manifestations and interventions of post-burn cognitive defects, as well as the mechanisms involved in memory defect, including neuroinflammation, destruction of BBB, and hormone imbalance. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9672468/ /pubmed/36408414 http://dx.doi.org/10.3389/fnins.2022.1026152 Text en Copyright © 2022 Xie, Hu, Cheng and Yao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Xie, Chenchen Hu, Jun Cheng, Yong Yao, Zhongxiang Researches on cognitive sequelae of burn injury: Current status and advances |
title | Researches on cognitive sequelae of burn injury: Current status and advances |
title_full | Researches on cognitive sequelae of burn injury: Current status and advances |
title_fullStr | Researches on cognitive sequelae of burn injury: Current status and advances |
title_full_unstemmed | Researches on cognitive sequelae of burn injury: Current status and advances |
title_short | Researches on cognitive sequelae of burn injury: Current status and advances |
title_sort | researches on cognitive sequelae of burn injury: current status and advances |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672468/ https://www.ncbi.nlm.nih.gov/pubmed/36408414 http://dx.doi.org/10.3389/fnins.2022.1026152 |
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