The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis

BACKGROUND: Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others. MAIN BODY OF THE ABSTRACT: Certain miRNAs (non-coding RNA sequences) are in...

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Detalles Bibliográficos
Autores principales: AbdelMassih, Antoine, Agha, Hala, El-Saiedi, Sonia, El-Sisi, Amal, El Shershaby, Meryam, Gaber, Hanya, Ismail, Habiba-Allah, El-Husseiny, Nadine, Amin, Abeer Reda, ElBoraie, Aly, Ayad, Aya, Menshawey, Esraa, Sefein, Fady, Osman, Ibrahim Ihab, Moursi, Mai, Hanafy, Maram, Abdelaziz, Mariam Sherif, Arsanyous, Mariem Badr, Khaled-Ibn-El-Walid, Mariam, Tawfik, Marwa Gamal, Habib, Menna, Mansour, Mina Ehab, Ashraf, Mirette, Khattab, Mohamed Ayman, Alshehry, Nada, Hafez, Nada, ElDeeb, Naheel Essam, Ashraf, Nirvana, Khalil, Noha, AbdElSalam, Noheir Ismail, Shebl, Noura, Hafez, Nouran Gamal Ali, Youssef, Nourhan Hatem, Bahnan, Odette, Ismail, Passant, Kelada, Peter, Menshawey, Rahma, Saeed, Rana, Husseiny, Reem Jalal, Yasser, Reem, Sharaf, Safa, Adel, Veronia, Naeem, Youstina, Nicola, Youstina Nagy Farid, Kamel, Aya, Hozaien, Rafeef, Fouda, Raghda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672617/
https://www.ncbi.nlm.nih.gov/pubmed/36415483
http://dx.doi.org/10.1186/s42269-022-00955-1
Descripción
Sumario:BACKGROUND: Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others. MAIN BODY OF THE ABSTRACT: Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis. SHORT CONCLUSION: In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.

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