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Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline

Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC), Victoria's vaccine safety service for reporting adverse events following immunisation (AEFI), has provided integrated spontaneous surveillance and clinical services for individuals affected by AEFI since 2007. We d...

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Autores principales: Laemmle-Ruff, Ingrid, Lewis, Georgina, Clothier, Hazel J., Dimaguila, Gerardo Luis, Wolthuizen, Michelle, Buttery, Jim, Crawford, Nigel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672672/
https://www.ncbi.nlm.nih.gov/pubmed/36408022
http://dx.doi.org/10.3389/fpubh.2022.1053637
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author Laemmle-Ruff, Ingrid
Lewis, Georgina
Clothier, Hazel J.
Dimaguila, Gerardo Luis
Wolthuizen, Michelle
Buttery, Jim
Crawford, Nigel W.
author_facet Laemmle-Ruff, Ingrid
Lewis, Georgina
Clothier, Hazel J.
Dimaguila, Gerardo Luis
Wolthuizen, Michelle
Buttery, Jim
Crawford, Nigel W.
author_sort Laemmle-Ruff, Ingrid
collection PubMed
description Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC), Victoria's vaccine safety service for reporting adverse events following immunisation (AEFI), has provided integrated spontaneous surveillance and clinical services for individuals affected by AEFI since 2007. We describe SAEFVIC's response to the COVID-19 vaccine program, and reflect on lessons learned for vaccine safety. The massive scale of the Australian COVID-19 vaccine program required rapid adaptations across all aspects of SAEFVIC's vaccine safety services. Collection of AEFI reports was streamlined and expanded, incorporating both spontaneous and active surveillance data. Dramatically increased report volumes were managed with additional staffing, and innovations to automate, filter, and triage reports for priority follow up. There were two major adverse events of special interest (AESI): thrombosis with thrombocytopaenia syndrome and myocarditis, with multiple other AESI also investigated. Rapid escalation mechanisms to respond to AESI were established, along with AESI-specific databases for enhanced monitoring. Vaccine education and training resources were developed and public-facing vaccine safety reports updated weekly. Frequent communication with local and national government and regulatory bodies, and consultation with specialist groups was essential. The COVID-19 vaccine program has highlighted the importance of vaccine safety in supporting public confidence in vaccines and informing evidence-based immunisation policy. Supporting the COVID-19 vaccine program has required flexibility in adapting to policy changes and evolving vaccine safety signals, careful triage and prioritisation, informatics innovation, and enhanced engagement with the public regarding vaccine safety. Long-term investment to continue strengthening vaccine safety systems, building on lessons learned, will be essential for the ongoing success of Australian vaccination programs.
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spelling pubmed-96726722022-11-19 Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline Laemmle-Ruff, Ingrid Lewis, Georgina Clothier, Hazel J. Dimaguila, Gerardo Luis Wolthuizen, Michelle Buttery, Jim Crawford, Nigel W. Front Public Health Public Health Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC), Victoria's vaccine safety service for reporting adverse events following immunisation (AEFI), has provided integrated spontaneous surveillance and clinical services for individuals affected by AEFI since 2007. We describe SAEFVIC's response to the COVID-19 vaccine program, and reflect on lessons learned for vaccine safety. The massive scale of the Australian COVID-19 vaccine program required rapid adaptations across all aspects of SAEFVIC's vaccine safety services. Collection of AEFI reports was streamlined and expanded, incorporating both spontaneous and active surveillance data. Dramatically increased report volumes were managed with additional staffing, and innovations to automate, filter, and triage reports for priority follow up. There were two major adverse events of special interest (AESI): thrombosis with thrombocytopaenia syndrome and myocarditis, with multiple other AESI also investigated. Rapid escalation mechanisms to respond to AESI were established, along with AESI-specific databases for enhanced monitoring. Vaccine education and training resources were developed and public-facing vaccine safety reports updated weekly. Frequent communication with local and national government and regulatory bodies, and consultation with specialist groups was essential. The COVID-19 vaccine program has highlighted the importance of vaccine safety in supporting public confidence in vaccines and informing evidence-based immunisation policy. Supporting the COVID-19 vaccine program has required flexibility in adapting to policy changes and evolving vaccine safety signals, careful triage and prioritisation, informatics innovation, and enhanced engagement with the public regarding vaccine safety. Long-term investment to continue strengthening vaccine safety systems, building on lessons learned, will be essential for the ongoing success of Australian vaccination programs. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9672672/ /pubmed/36408022 http://dx.doi.org/10.3389/fpubh.2022.1053637 Text en Copyright © 2022 Laemmle-Ruff, Lewis, Clothier, Dimaguila, Wolthuizen, Buttery and Crawford. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Laemmle-Ruff, Ingrid
Lewis, Georgina
Clothier, Hazel J.
Dimaguila, Gerardo Luis
Wolthuizen, Michelle
Buttery, Jim
Crawford, Nigel W.
Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline
title Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline
title_full Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline
title_fullStr Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline
title_full_unstemmed Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline
title_short Vaccine safety in Australia during the COVID-19 pandemic: Lessons learned on the frontline
title_sort vaccine safety in australia during the covid-19 pandemic: lessons learned on the frontline
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672672/
https://www.ncbi.nlm.nih.gov/pubmed/36408022
http://dx.doi.org/10.3389/fpubh.2022.1053637
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