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Clinical implication of recent randomized control trial in primary angle-closure disease management

Blindness due to primary angle-closure glaucoma (PACG) can be reduced significantly if the ongoing angle-closure process is arrested at an early stage. Various treatments such as laser peripheral iridotomy (LPI), iridoplasty, and clear lens extraction (CLE) have been advocated as first-line therapy...

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Autores principales: Parikh, Shefali R, Parikh, Rajul S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672731/
https://www.ncbi.nlm.nih.gov/pubmed/35918922
http://dx.doi.org/10.4103/ijo.IJO_1807_21
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author Parikh, Shefali R
Parikh, Rajul S
author_facet Parikh, Shefali R
Parikh, Rajul S
author_sort Parikh, Shefali R
collection PubMed
description Blindness due to primary angle-closure glaucoma (PACG) can be reduced significantly if the ongoing angle-closure process is arrested at an early stage. Various treatments such as laser peripheral iridotomy (LPI), iridoplasty, and clear lens extraction (CLE) have been advocated as first-line therapy for primary angle-closure (PAC), PACG, and high-risk cases of primary angle-closure suspect (PACS). EAGLE study, propagated the effectiveness of CLE over LPI for the management of primary angle closure and have sparked controversy regarding the role of LPI as a first line procedure. Randomized controlled trials (RCT), systematic reviews, and meta-analyses of RCTs done on the same question provide us with a solid base for creating guidelines/modules for our day-to-day clinical practice. A systematic review was conducted, searching several databases, including PubMed, Cochrane Library, EMBASE, and ClinicalTrials.gov, for the last 16 years (January 2005–December 2021) for RCTs with data published related to primary angle-closure disease (PACD). The search strategy included the following terms: “Primary Angle Closure disease,” “Primary Angle Closure Glaucoma,” “Primary Angle Closure,” “Primary Angle Closure Suspect,” “clear lens extraction,” “laser iridotomy,” “laser peripheral iridotomy,” “argon laser peripheral iridoplasty,” “selective laser trabeculoplasty,” “trabeculectomy,” “randomized control trial,” and “meta-analysis of randomized control trial.” In this review, we will discuss recently published RCTs (within the last 16 years) for the management of PACD and their clinical implications in day-to-day practice.
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spelling pubmed-96727312022-11-19 Clinical implication of recent randomized control trial in primary angle-closure disease management Parikh, Shefali R Parikh, Rajul S Indian J Ophthalmol Review Article Blindness due to primary angle-closure glaucoma (PACG) can be reduced significantly if the ongoing angle-closure process is arrested at an early stage. Various treatments such as laser peripheral iridotomy (LPI), iridoplasty, and clear lens extraction (CLE) have been advocated as first-line therapy for primary angle-closure (PAC), PACG, and high-risk cases of primary angle-closure suspect (PACS). EAGLE study, propagated the effectiveness of CLE over LPI for the management of primary angle closure and have sparked controversy regarding the role of LPI as a first line procedure. Randomized controlled trials (RCT), systematic reviews, and meta-analyses of RCTs done on the same question provide us with a solid base for creating guidelines/modules for our day-to-day clinical practice. A systematic review was conducted, searching several databases, including PubMed, Cochrane Library, EMBASE, and ClinicalTrials.gov, for the last 16 years (January 2005–December 2021) for RCTs with data published related to primary angle-closure disease (PACD). The search strategy included the following terms: “Primary Angle Closure disease,” “Primary Angle Closure Glaucoma,” “Primary Angle Closure,” “Primary Angle Closure Suspect,” “clear lens extraction,” “laser iridotomy,” “laser peripheral iridotomy,” “argon laser peripheral iridoplasty,” “selective laser trabeculoplasty,” “trabeculectomy,” “randomized control trial,” and “meta-analysis of randomized control trial.” In this review, we will discuss recently published RCTs (within the last 16 years) for the management of PACD and their clinical implications in day-to-day practice. Wolters Kluwer - Medknow 2022-08 2022-07-29 /pmc/articles/PMC9672731/ /pubmed/35918922 http://dx.doi.org/10.4103/ijo.IJO_1807_21 Text en Copyright: © 2022 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Parikh, Shefali R
Parikh, Rajul S
Clinical implication of recent randomized control trial in primary angle-closure disease management
title Clinical implication of recent randomized control trial in primary angle-closure disease management
title_full Clinical implication of recent randomized control trial in primary angle-closure disease management
title_fullStr Clinical implication of recent randomized control trial in primary angle-closure disease management
title_full_unstemmed Clinical implication of recent randomized control trial in primary angle-closure disease management
title_short Clinical implication of recent randomized control trial in primary angle-closure disease management
title_sort clinical implication of recent randomized control trial in primary angle-closure disease management
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672731/
https://www.ncbi.nlm.nih.gov/pubmed/35918922
http://dx.doi.org/10.4103/ijo.IJO_1807_21
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