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Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa

In Sub-Saharan Africa (SSA) endothelial dysfunction (ED) and chronic inflammation in the HIV-positive adults population who are on highly active antiretroviral therapy (HAART) are not fully explored. We determined the effect of HAART on chronic inflammation and ED among HAART-exposed adults in a rur...

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Autores principales: Hanser, Sidney, Mphekgwana, Peter Modupi, Moraba, Mpho Matthias, Erasmus, Lourens, van Staden, Marlise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672841/
https://www.ncbi.nlm.nih.gov/pubmed/36407976
http://dx.doi.org/10.3389/fpubh.2022.980754
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author Hanser, Sidney
Mphekgwana, Peter Modupi
Moraba, Mpho Matthias
Erasmus, Lourens
van Staden, Marlise
author_facet Hanser, Sidney
Mphekgwana, Peter Modupi
Moraba, Mpho Matthias
Erasmus, Lourens
van Staden, Marlise
author_sort Hanser, Sidney
collection PubMed
description In Sub-Saharan Africa (SSA) endothelial dysfunction (ED) and chronic inflammation in the HIV-positive adults population who are on highly active antiretroviral therapy (HAART) are not fully explored. We determined the effect of HAART on chronic inflammation and ED among HAART-exposed adults in a rural setting. Weight and height were measured to quantify the body mass index (BMI). Lipid and Glucose levels were determined. C-reactive protein (CRP), L-selectin, soluble intercellular adhesion molecule (sICAM-1), and soluble vascular cell adhesion molecule (sVCAM-1) in serum samples were tested. The majority of the HAART-exposed group were on treatment for <5 years. Soluble intercellular adhesion molecules, sVCAM-1, L-selectin and CRP were elevated in the HIV-infected groups as compared to the control group. The multivariate analysis showed that HIV infection (HAART-naïve) associated with increased sICAM-1 (β = 0.350; 95% CI: 0.035–0.664, p = 0.029) and L-selectin (β = 0.236; 95% CI: 0.038–0.434, p = 0.019) but not sVCAM-1 (β = 0.009; 95% CI: 0.252–0.270, p = 0.468). The HAART-exposed group is associated with sVCAM-1 (β = 0.250; 95% CI: 0.015–0.486, p = 0.037) but not with sICAM-1- (β = 0.253; 95% CI: −0.083–0.590, p = 0.14) and L-selectin (β = 0.119; 95% CI: −0.016–0.253, p = 0.084). sVCAM-1 was associated with decreased alcohol consumption (β = −0.245; 95% CI: −0.469–0.021, p = 0.032) while L-selectin was associated with decreased total cholesterol (β = −0.061; 95% CI: −0.124–0.002, p = 0.05) and increased CRP (β = 0.015; 95% CI: 0.009–0.022, p < 0.001). Increased endothelial biomarkers were associated with HIV disease and HAART in a rural black adult population of African descent after controlling for CVD risk factors. Inflammation (as measured with CRP) may play an important role in endothelial activation. Further studies are needed to explore the association between endothelial dysfunction and inflammation especially among the HIV-positive population on HAART in similar settings.
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spelling pubmed-96728412022-11-19 Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa Hanser, Sidney Mphekgwana, Peter Modupi Moraba, Mpho Matthias Erasmus, Lourens van Staden, Marlise Front Public Health Public Health In Sub-Saharan Africa (SSA) endothelial dysfunction (ED) and chronic inflammation in the HIV-positive adults population who are on highly active antiretroviral therapy (HAART) are not fully explored. We determined the effect of HAART on chronic inflammation and ED among HAART-exposed adults in a rural setting. Weight and height were measured to quantify the body mass index (BMI). Lipid and Glucose levels were determined. C-reactive protein (CRP), L-selectin, soluble intercellular adhesion molecule (sICAM-1), and soluble vascular cell adhesion molecule (sVCAM-1) in serum samples were tested. The majority of the HAART-exposed group were on treatment for <5 years. Soluble intercellular adhesion molecules, sVCAM-1, L-selectin and CRP were elevated in the HIV-infected groups as compared to the control group. The multivariate analysis showed that HIV infection (HAART-naïve) associated with increased sICAM-1 (β = 0.350; 95% CI: 0.035–0.664, p = 0.029) and L-selectin (β = 0.236; 95% CI: 0.038–0.434, p = 0.019) but not sVCAM-1 (β = 0.009; 95% CI: 0.252–0.270, p = 0.468). The HAART-exposed group is associated with sVCAM-1 (β = 0.250; 95% CI: 0.015–0.486, p = 0.037) but not with sICAM-1- (β = 0.253; 95% CI: −0.083–0.590, p = 0.14) and L-selectin (β = 0.119; 95% CI: −0.016–0.253, p = 0.084). sVCAM-1 was associated with decreased alcohol consumption (β = −0.245; 95% CI: −0.469–0.021, p = 0.032) while L-selectin was associated with decreased total cholesterol (β = −0.061; 95% CI: −0.124–0.002, p = 0.05) and increased CRP (β = 0.015; 95% CI: 0.009–0.022, p < 0.001). Increased endothelial biomarkers were associated with HIV disease and HAART in a rural black adult population of African descent after controlling for CVD risk factors. Inflammation (as measured with CRP) may play an important role in endothelial activation. Further studies are needed to explore the association between endothelial dysfunction and inflammation especially among the HIV-positive population on HAART in similar settings. Frontiers Media S.A. 2022-11-04 /pmc/articles/PMC9672841/ /pubmed/36407976 http://dx.doi.org/10.3389/fpubh.2022.980754 Text en Copyright © 2022 Hanser, Mphekgwana, Moraba, Erasmus and van Staden. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Hanser, Sidney
Mphekgwana, Peter Modupi
Moraba, Mpho Matthias
Erasmus, Lourens
van Staden, Marlise
Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa
title Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa
title_full Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa
title_fullStr Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa
title_full_unstemmed Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa
title_short Increased endothelial biomarkers are associated with HIV antiretroviral therapy and C-reactive protein among a African rural population in Limpopo Province, South Africa
title_sort increased endothelial biomarkers are associated with hiv antiretroviral therapy and c-reactive protein among a african rural population in limpopo province, south africa
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672841/
https://www.ncbi.nlm.nih.gov/pubmed/36407976
http://dx.doi.org/10.3389/fpubh.2022.980754
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