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PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones
Animal organs maintain tissue integrity and ensure removal of aberrant cells through several types of surveillance mechanisms. One prominent example is the elimination of polarity-deficient mutant cells within developing Drosophila imaginal discs. This has been proposed to require heterotypic cell c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672856/ https://www.ncbi.nlm.nih.gov/pubmed/36355597 http://dx.doi.org/10.1242/bio.059525 |
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author | Gerlach, Stephan U. de Vreede, Geert Bilder, David |
author_facet | Gerlach, Stephan U. de Vreede, Geert Bilder, David |
author_sort | Gerlach, Stephan U. |
collection | PubMed |
description | Animal organs maintain tissue integrity and ensure removal of aberrant cells through several types of surveillance mechanisms. One prominent example is the elimination of polarity-deficient mutant cells within developing Drosophila imaginal discs. This has been proposed to require heterotypic cell competition dependent on the receptor tyrosine phosphatase PTP10D within the mutant cells. We report here experiments to test this requirement in various contexts and find that PTP10D is not obligately required for the removal of scribble (scrib) mutant and similar polarity-deficient cells. Our experiments used identical stocks with which another group can detect the PTP10D requirement, and our results do not vary under several husbandry conditions including high and low protein food diets. Although we are unable to identify the source of the discrepant results, we suggest that the role of PTP10D in polarity-deficient cell elimination may not be absolute. |
format | Online Article Text |
id | pubmed-9672856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-96728562022-11-18 PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones Gerlach, Stephan U. de Vreede, Geert Bilder, David Biol Open Research Article Animal organs maintain tissue integrity and ensure removal of aberrant cells through several types of surveillance mechanisms. One prominent example is the elimination of polarity-deficient mutant cells within developing Drosophila imaginal discs. This has been proposed to require heterotypic cell competition dependent on the receptor tyrosine phosphatase PTP10D within the mutant cells. We report here experiments to test this requirement in various contexts and find that PTP10D is not obligately required for the removal of scribble (scrib) mutant and similar polarity-deficient cells. Our experiments used identical stocks with which another group can detect the PTP10D requirement, and our results do not vary under several husbandry conditions including high and low protein food diets. Although we are unable to identify the source of the discrepant results, we suggest that the role of PTP10D in polarity-deficient cell elimination may not be absolute. The Company of Biologists Ltd 2022-11-10 /pmc/articles/PMC9672856/ /pubmed/36355597 http://dx.doi.org/10.1242/bio.059525 Text en © 2022. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Gerlach, Stephan U. de Vreede, Geert Bilder, David PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
title | PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
title_full | PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
title_fullStr | PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
title_full_unstemmed | PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
title_short | PTP10D-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
title_sort | ptp10d-mediated cell competition is not obligately required for elimination of polarity-deficient clones |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672856/ https://www.ncbi.nlm.nih.gov/pubmed/36355597 http://dx.doi.org/10.1242/bio.059525 |
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