Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta()()

OBJECTIVE: Osteogenesis imperfecta (OI) is a congenital disorder characterized by muscle defect and skeletal fragility, and no cure is yet available. Crosstalk between bone and muscle has become a new coming focus of therapeutic strategy in OI. Irisin, a secreted myokine, was found to be involved in...

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Detalles Bibliográficos
Autores principales: Sun, Bin, Wu, Huiqiao, Lu, Jiajia, Zhang, Rongcheng, Shen, Xiaolong, Gu, Yifei, Shi, Changgui, Zhang, Ying, Yuan, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672882/
https://www.ncbi.nlm.nih.gov/pubmed/36439629
http://dx.doi.org/10.1016/j.jot.2022.10.012

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