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Endothelial Acid Sphingomyelinase Promotes NLRP3 Inflammasome and Neointima Formation During Hypercholesterolemia

The NOD-like receptor pyrin domain 3 (NLRP3) inflammasome is activated during atherogenesis, but how this occurs is unclear. Here, we explored the mechanisms activating and regulating NLRP3 inflammasomes via the acid sphingomyelinase (ASM)-ceramide signaling pathway. As a neointima formation model,...

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Detalles Bibliográficos
Autores principales:	Yuan, Xinxu, Bhat, Owais M., Zou, Yao, Li, Xiang, Zhang, Yang, Li, Pin-Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672920/ https://www.ncbi.nlm.nih.gov/pubmed/36252682 http://dx.doi.org/10.1016/j.jlr.2022.100298

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