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Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila

Animals form sensory associations and store them as memories to guide behavioral decisions. Although unimodal learning has been studied extensively in insects, it is important to explore sensory cues in combination because most behaviors require multimodal inputs. In our study, we optimized the T-ma...

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Autores principales: Thiagarajan, Devasena, Eberl, Franziska, Veit, Daniel, Hansson, Bill S., Knaden, Markus, Sachse, Silke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672954/
https://www.ncbi.nlm.nih.gov/pubmed/36404920
http://dx.doi.org/10.1016/j.isci.2022.105485
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author Thiagarajan, Devasena
Eberl, Franziska
Veit, Daniel
Hansson, Bill S.
Knaden, Markus
Sachse, Silke
author_facet Thiagarajan, Devasena
Eberl, Franziska
Veit, Daniel
Hansson, Bill S.
Knaden, Markus
Sachse, Silke
author_sort Thiagarajan, Devasena
collection PubMed
description Animals form sensory associations and store them as memories to guide behavioral decisions. Although unimodal learning has been studied extensively in insects, it is important to explore sensory cues in combination because most behaviors require multimodal inputs. In our study, we optimized the T-maze to employ both visual and olfactory cues in a classical aversive learning paradigm in Drosophila melanogaster. In contrast to unimodal training, bimodal training evoked a significant short-term visual memory after a single training trial. Interestingly, the same protocol did not enhance short-term olfactory memory and even had a negative impact. However, compromised long-lasting olfactory memory significantly improved after bimodal training. Our study demonstrates that the effect of bimodal integration on learning is not always beneficial and is conditional upon the formed memory strengths. We postulate that flies utilize information on a need-to basis: bimodal training augments weakly formed memories while stronger associations are impacted differently.
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spelling pubmed-96729542022-11-19 Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila Thiagarajan, Devasena Eberl, Franziska Veit, Daniel Hansson, Bill S. Knaden, Markus Sachse, Silke iScience Article Animals form sensory associations and store them as memories to guide behavioral decisions. Although unimodal learning has been studied extensively in insects, it is important to explore sensory cues in combination because most behaviors require multimodal inputs. In our study, we optimized the T-maze to employ both visual and olfactory cues in a classical aversive learning paradigm in Drosophila melanogaster. In contrast to unimodal training, bimodal training evoked a significant short-term visual memory after a single training trial. Interestingly, the same protocol did not enhance short-term olfactory memory and even had a negative impact. However, compromised long-lasting olfactory memory significantly improved after bimodal training. Our study demonstrates that the effect of bimodal integration on learning is not always beneficial and is conditional upon the formed memory strengths. We postulate that flies utilize information on a need-to basis: bimodal training augments weakly formed memories while stronger associations are impacted differently. Elsevier 2022-11-03 /pmc/articles/PMC9672954/ /pubmed/36404920 http://dx.doi.org/10.1016/j.isci.2022.105485 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thiagarajan, Devasena
Eberl, Franziska
Veit, Daniel
Hansson, Bill S.
Knaden, Markus
Sachse, Silke
Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila
title Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila
title_full Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila
title_fullStr Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila
title_full_unstemmed Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila
title_short Aversive Bimodal Associations Differently Impact Visual and Olfactory Memory Performance in Drosophila
title_sort aversive bimodal associations differently impact visual and olfactory memory performance in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672954/
https://www.ncbi.nlm.nih.gov/pubmed/36404920
http://dx.doi.org/10.1016/j.isci.2022.105485
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