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Diminished arachidonate 5-lipoxygenase perturbs phase separation and transcriptional response of Runx2 to reverse pathological ventricular remodeling

BACKGROUND: Arachidonate 5-lipoxygenase (Alox5) belongs to a class of nonheme iron-containing dioxygenases involved in the catalysis of leukotriene biosynthesis. However, the effects of Alox5 itself on pathological cardiac remodeling and heart failure remain elusive. METHODS: The role of Alox5 in pa...

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Detalles Bibliográficos
Autores principales:	Xie, Saiyang, Chen, Mengya, Fang, Wenxi, Liu, Shiqiang, Wu, Qingqing, Liu, Chen, Xing, Yun, Shi, Wenke, Xu, Man, Zhang, Min, Chen, Si, Zeng, Xiaofeng, Wang, Shasha, Deng, Wei, Tang, Qizhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9672960/ https://www.ncbi.nlm.nih.gov/pubmed/36395739 http://dx.doi.org/10.1016/j.ebiom.2022.104359

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