Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial

IMPORTANCE: Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed. OBJECTIVE: To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among p...

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Detalles Bibliográficos
Autores principales: Liau, Linda M., Ashkan, Keyoumars, Brem, Steven, Campian, Jian L., Trusheim, John E., Iwamoto, Fabio M., Tran, David D., Ansstas, George, Cobbs, Charles S., Heth, Jason A., Salacz, Michael E., D’Andre, Stacy, Aiken, Robert D., Moshel, Yaron A., Nam, Joo Y., Pillainayagam, Clement P., Wagner, Stephanie A., Walter, Kevin A., Chaudhary, Rekha, Goldlust, Samuel A., Lee, Ian Y., Bota, Daniela A., Elinzano, Heinrich, Grewal, Jai, Lillehei, Kevin, Mikkelsen, Tom, Walbert, Tobias, Abram, Steven, Brenner, Andrew J., Ewend, Matthew G., Khagi, Simon, Lovick, Darren S., Portnow, Jana, Kim, Lyndon, Loudon, William G., Martinez, Nina L., Thompson, Reid C., Avigan, David E., Fink, Karen L., Geoffroy, Francois J., Giglio, Pierre, Gligich, Oleg, Krex, Dietmar, Lindhorst, Scott M., Lutzky, Jose, Meisel, Hans-Jörg, Nadji-Ohl, Minou, Sanchin, Lhagva, Sloan, Andrew, Taylor, Lynne P., Wu, Julian K., Dunbar, Erin M., Etame, Arnold B., Kesari, Santosh, Mathieu, David, Piccioni, David E., Baskin, David S., Lacroix, Michel, May, Sven-Axel, New, Pamela Z., Pluard, Timothy J., Toms, Steven A., Tse, Victor, Peak, Scott, Villano, John L., Battiste, James D., Mulholland, Paul J., Pearlman, Michael L., Petrecca, Kevin, Schulder, Michael, Prins, Robert M., Boynton, Alton L., Bosch, Marnix L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673026/
https://www.ncbi.nlm.nih.gov/pubmed/36394838
http://dx.doi.org/10.1001/jamaoncol.2022.5370

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