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Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo

BACKGROUND: s: Hyperhomocysteinemia (HHcy) is one of risk factors for vascular cognitive impairment (VCI). GTP cyclohydrolase 1 (GCH1) deficiency is critical to oxidative stress in vascular dysfunction. The aim of this study was designed to examine whether HHcy induces VCI through GCH1 S-nitrosylati...

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Detalles Bibliográficos
Autores principales:	Yin, Ya-Ling, Chen, Yuan, Ren, Feng, Wang, Lu, Zhu, Mo-Li, Lu, Jun-Xiu, Wang, Qian-Qian, Lu, Cheng-Biao, Liu, Chao, Bai, Yong-Ping, Wang, Shuang-Xi, Wang, Jian-Zhi, Li, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673109/ https://www.ncbi.nlm.nih.gov/pubmed/36399957 http://dx.doi.org/10.1016/j.redox.2022.102540

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