Cargando…

Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins

Statins have manifold protective effects on the cardiovascular system. In addition to lowering LDL cholesterol levels, statins also have antioxidant effects on cardiovascular tissues involving intracellular redox pathways that are incompletely understood. Inhibition of HMG-CoA reductase by statins n...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waldeck-Weiermair, Markus, Yadav, Shambhu, Kaynert, Jonas, Thulabandu, Venkata Revanth, Pandey, Arvind K., Spyropoulos, Fotios, Covington, Taylor, Das, Apabrita Ayan, Krüger, Christina, Michel, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673117/ https://www.ncbi.nlm.nih.gov/pubmed/36401888 http://dx.doi.org/10.1016/j.redox.2022.102539

Ejemplares similares

Sensory ataxia and cardiac hypertrophy caused by neurovascular oxidative stress in chemogenetic transgenic mouse lines
por: Yadav, Shambhu, et al.
Publicado: (2023)

AQP8 is a crucial H(2)O(2) transporter in insulin-producing RINm5F cells
por: Krüger, Christina, et al.
Publicado: (2021)

Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells
por: Pandey, Arvind K., et al.
Publicado: (2022)

NOX isoforms in the development of abdominal aortic aneurysm
por: Siu, Kin Lung, et al.
Publicado: (2016)

Rac-dependent feedforward autoactivation of NOX2 leads to oxidative burst
por: Hoang, Hanh My, et al.
Publicado: (2021)

Pharmacological characterization of the seven human NOX isoforms and their inhibitors
por: Augsburger, Fiona, et al.
Publicado: (2019)

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor
por: Nisimoto, Yukio, et al.
Publicado: (2014)

Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers
por: Henninger, Christian, et al.
Publicado: (2017)

Real-time visualization of distinct nitric oxide generation of nitric oxide synthase isoforms in single cells
por: Eroglu, Emrah, et al.
Publicado: (2017)

Regulation of serine palmitoyl-transferase and Rac1–Nox2 signaling in diabetic retinopathy
por: Alka, Kumari, et al.
Publicado: (2022)

Correction to Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor
por: Nisimoto, Yukio, et al.
Publicado: (2014)

Statins attenuate cholesterol-induced ROS via inhibiting NOX2/NOX4 and mitochondrial pathway in collecting ducts of the kidney
por: Wang, Ani, et al.
Publicado: (2022)

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
por: Baugher, Paige J, et al.
Publicado: (2005)

NOX family NADPH oxidases in mammals: Evolutionary conservation and isoform-defining sequences
por: Nazari, Bahareh, et al.
Publicado: (2023)

Nox Gene Expression and Cytochemical Localization of Hydrogen Peroxide in Polyporus umbellatus Sclerotial Formation
por: Xing, Yong-Mei, et al.
Publicado: (2013)

EZH2 modulates retinoic acid signaling to ensure myotube formation during development
por: Thulabandu, Venkata, et al.
Publicado: (2022)

Aminoguanidine inhibits aortic hydrogen peroxide production, VSMC NOX activity and hypercontractility in diabetic mice
por: Oak, Jeong-Ho, et al.
Publicado: (2009)

DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway
por: Kang, M A, et al.
Publicado: (2012)

Endothelial mitochondria—less respiration, more integration
por: Groschner, Lukas N., et al.
Publicado: (2012)

Nox
por: Hettche, Thomas, 1964-
Publicado: (1996)

GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS
por: Koehn, Olivia J., et al.
Publicado: (2023)

NOX4–TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming
por: Pandey, Jyotsana, et al.
Publicado: (2023)

Intracellular Ca(2+) release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum
por: Gottschalk, Benjamin, et al.
Publicado: (2018)

NADPH Oxidase Isoform 2 (NOX2) Is Involved in Drug Addiction Vulnerability in Progeny Developmentally Exposed to Ethanol
por: Contreras, Marcela L., et al.
Publicado: (2017)

Importance of cholesterol-rich microdomains in the regulation of Nox isoforms and redox signaling in human vascular smooth muscle cells
por: Anagnostopoulou, Aikaterini, et al.
Publicado: (2020)

NOX4-Dependent Hydrogen Peroxide Overproduction in Human Atrial Fibrillation and HL-1 Atrial Cells: Relationship to Hypertension
por: Zhang, Jun, et al.
Publicado: (2012)

The preventive effect of atorvastatin on liver fibrosis in the bile duct ligation rats via antioxidant activity and down-regulation of Rac1 and NOX1
por: Ghoreshi, Zohreh-al-sadat, et al.
Publicado: (2020)

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation
por: Fu, Hang, et al.
Publicado: (2019)

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases
por: Park, Min Woo, et al.
Publicado: (2021)

GPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells
por: Bondarenko, Alexander, et al.
Publicado: (2010)

Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction
por: Madreiter-Sokolowski, Corina T., et al.
Publicado: (2018)

Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity
por: Muñoz, Mercedes, et al.
Publicado: (2019)

Hyaluronic acid-coated polymeric micelles with hydrogen peroxide scavenging to encapsulate statins for alleviating atherosclerosis
por: Mu, Dan, et al.
Publicado: (2020)

Effects of NADPH Oxidase Isoform-2 (NOX2) Inhibition on Behavioral Responses and Neuroinflammation in a Mouse Model of Neuropathic Pain
por: Teixeira-Santos, Luísa, et al.
Publicado: (2023)

NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction
por: Taylor-Fishwick, David A.
Publicado: (2013)

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity
por: Prior, Kim-Kristin, et al.
Publicado: (2016)

Redox Reaction Triggered Nanomotors Based on Soft-Oxometalates With High and Sustained Motility
por: Mallick, Apabrita, et al.
Publicado: (2018)

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation()
por: Walsh, T.G., et al.
Publicado: (2014)

Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signals
por: Waldeck-Weiermair, Markus, et al.
Publicado: (2010)

TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation
por: Hofmann, Nicole A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_t9tdhrtir686sualfur2gp2rhm