Cargando…

In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer

OBJECTIVES: We aim to contribute to the assessment of the screening performance in Flanders (Belgium) and to identify valuable mammograms for subsequent studies and training. MATERIALS AND METHODS: Initially negative prior screening mammograms (sMx) of 210 women with confirmed breast cancer detected...

Descripción completa

Detalles Bibliográficos
Autores principales: Vandendaele, Lieve, Jidkova, Svetlana, Van Herck, Koen, Kimpe, Tom, Verschuere, Veerle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673605/
https://www.ncbi.nlm.nih.gov/pubmed/36447632
http://dx.doi.org/10.5334/jbsr.2796
_version_ 1784832978481840128
author Vandendaele, Lieve
Jidkova, Svetlana
Van Herck, Koen
Kimpe, Tom
Verschuere, Veerle
author_facet Vandendaele, Lieve
Jidkova, Svetlana
Van Herck, Koen
Kimpe, Tom
Verschuere, Veerle
author_sort Vandendaele, Lieve
collection PubMed
description OBJECTIVES: We aim to contribute to the assessment of the screening performance in Flanders (Belgium) and to identify valuable mammograms for subsequent studies and training. MATERIALS AND METHODS: Initially negative prior screening mammograms (sMx) of 210 women with confirmed breast cancer detected by the Flemish screening programme between 2011–2013 were reviewed by a highly experienced radiologist. The review of the prior sMx was performed in three steps: 1) only prior mammograms available; 2) with index sMx (=subsequent positive sMx) present; 3) with index sMx and clinical information present. RESULTS: The radiological review yielded 94 (45%) mammograms ‘without suspicious lesions’, 77 (37%) ‘with minimal signs in at least one breast’, and 39 (19%) ‘with clearly visible tumours’. In univariate analyses, the reclassification of prior sMx was significantly associated with the date of the prior sMx, the need for a third reader for arbitration, image quality and the detector system used (computed radiography versus direct readout digital radiography), and it was not associated with the interval between screening rounds, age at prior sMx, breast density, or tumour characteristics (<T2 versus ≥T2, in situ versus invasive). In multivariate analyses, the date of the prior sMx (p = 0.001), need for arbitration (p = 0.001) and image quality (p < 0.001) remained significantly associated with the reclassification. CONCLUSION: This retrospective review reclassified 19% of the sMx as clearly visible tumours. With this, the Flemish screening programme performs in accordance with similar studies. The sMx reviewed in this study, form a valuable set of mammograms for training and further research.
format Online
Article
Text
id pubmed-9673605
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Ubiquity Press
record_format MEDLINE/PubMed
spelling pubmed-96736052022-11-28 In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer Vandendaele, Lieve Jidkova, Svetlana Van Herck, Koen Kimpe, Tom Verschuere, Veerle J Belg Soc Radiol Original Article OBJECTIVES: We aim to contribute to the assessment of the screening performance in Flanders (Belgium) and to identify valuable mammograms for subsequent studies and training. MATERIALS AND METHODS: Initially negative prior screening mammograms (sMx) of 210 women with confirmed breast cancer detected by the Flemish screening programme between 2011–2013 were reviewed by a highly experienced radiologist. The review of the prior sMx was performed in three steps: 1) only prior mammograms available; 2) with index sMx (=subsequent positive sMx) present; 3) with index sMx and clinical information present. RESULTS: The radiological review yielded 94 (45%) mammograms ‘without suspicious lesions’, 77 (37%) ‘with minimal signs in at least one breast’, and 39 (19%) ‘with clearly visible tumours’. In univariate analyses, the reclassification of prior sMx was significantly associated with the date of the prior sMx, the need for a third reader for arbitration, image quality and the detector system used (computed radiography versus direct readout digital radiography), and it was not associated with the interval between screening rounds, age at prior sMx, breast density, or tumour characteristics (<T2 versus ≥T2, in situ versus invasive). In multivariate analyses, the date of the prior sMx (p = 0.001), need for arbitration (p = 0.001) and image quality (p < 0.001) remained significantly associated with the reclassification. CONCLUSION: This retrospective review reclassified 19% of the sMx as clearly visible tumours. With this, the Flemish screening programme performs in accordance with similar studies. The sMx reviewed in this study, form a valuable set of mammograms for training and further research. Ubiquity Press 2022-11-11 /pmc/articles/PMC9673605/ /pubmed/36447632 http://dx.doi.org/10.5334/jbsr.2796 Text en Copyright: © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Vandendaele, Lieve
Jidkova, Svetlana
Van Herck, Koen
Kimpe, Tom
Verschuere, Veerle
In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer
title In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer
title_full In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer
title_fullStr In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer
title_full_unstemmed In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer
title_short In-depth Retrospective Review of Originally Negative Screening Mammograms from Women with Confirmed Breast Cancer
title_sort in-depth retrospective review of originally negative screening mammograms from women with confirmed breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673605/
https://www.ncbi.nlm.nih.gov/pubmed/36447632
http://dx.doi.org/10.5334/jbsr.2796
work_keys_str_mv AT vandendaelelieve indepthretrospectivereviewoforiginallynegativescreeningmammogramsfromwomenwithconfirmedbreastcancer
AT jidkovasvetlana indepthretrospectivereviewoforiginallynegativescreeningmammogramsfromwomenwithconfirmedbreastcancer
AT vanherckkoen indepthretrospectivereviewoforiginallynegativescreeningmammogramsfromwomenwithconfirmedbreastcancer
AT kimpetom indepthretrospectivereviewoforiginallynegativescreeningmammogramsfromwomenwithconfirmedbreastcancer
AT verschuereveerle indepthretrospectivereviewoforiginallynegativescreeningmammogramsfromwomenwithconfirmedbreastcancer