Cargando…
Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug‐Target Mendelian Randomization Study
BACKGROUND: PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are important therapeutic options for reducing cardiovascular disease risk; however, questions remain regarding potential differences in the neuropsychiatric impact of long‐term PCSK9 inhibition between men and women. METHO...
Autores principales: | Bell, Andrew S., Rosoff, Daniel B., Mavromatis, Lucas A., Jung, Jeesun, Wagner, Josephin, Lohoff, Falk W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673626/ https://www.ncbi.nlm.nih.gov/pubmed/36285785 http://dx.doi.org/10.1161/JAHA.122.026122 |
Ejemplares similares
-
Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries
por: Rosoff, Daniel B., et al.
Publicado: (2023) -
Multi-omic underpinnings of epigenetic aging and human longevity
por: Mavromatis, Lucas A., et al.
Publicado: (2023) -
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
por: Rosoff, Daniel B., et al.
Publicado: (2023) -
Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study
por: Mavromatis, Lucas A., et al.
Publicado: (2022) -
Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants
por: Rosoff, Daniel B., et al.
Publicado: (2019)