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Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure

BACKGROUND: Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10‐year‐old children. METHODS AND RESULTS: We included 2797 mother–offspri...

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Autores principales: Silva, Carolina C. V., Santos, Susana, Muetzel, Ryan L., Vernooij, Meike W., van Rijn, Bas B., Jaddoe, Vincent W. V., El Marroun, Hanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673736/
https://www.ncbi.nlm.nih.gov/pubmed/36193935
http://dx.doi.org/10.1161/JAHA.122.026133
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author Silva, Carolina C. V.
Santos, Susana
Muetzel, Ryan L.
Vernooij, Meike W.
van Rijn, Bas B.
Jaddoe, Vincent W. V.
El Marroun, Hanan
author_facet Silva, Carolina C. V.
Santos, Susana
Muetzel, Ryan L.
Vernooij, Meike W.
van Rijn, Bas B.
Jaddoe, Vincent W. V.
El Marroun, Hanan
author_sort Silva, Carolina C. V.
collection PubMed
description BACKGROUND: Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10‐year‐old children. METHODS AND RESULTS: We included 2797 mother–offspring pairs from the Generation R Study. Maternal body mass index, gestational weight gain, blood pressure, insulin, glucose, and lipid blood concentrations were obtained in early pregnancy. Childhood structural brain measures, including global metrics of brain tissue volumes and white matter microstructure, were quantified by magnetic resonance imaging at 10 years. As compared with offspring of mothers with normal weight, those of mothers with underweight had smaller total brain volume (difference, −28.99 [95% CI −56.55 to −1.45] cm(3)). Similarly, as compared with offspring of mothers with gestational weight gain between the 25th and 75th percentile, those of mothers with gestational weight loss or no gestational weight gain (<25th percentile), had smaller total brain volume (difference, −13.07 [95% CI, −23.82 to −2.32] cm(3)). Also, higher maternal diastolic blood pressure in early pregnancy was associated with lower offspring white matter mean diffusivity (difference, −0.07 [95% CI, −0.11 to −0.02] SD score). After multiple testing correction, only the association of maternal diastolic blood pressure with lower offspring white matter mean diffusivity remained statistically significant. No associations were observed of maternal insulin, glucose, and lipid concentrations with childhood brain outcomes. CONCLUSIONS: Our findings suggest that maternal cardiovascular health during pregnancy might be related to offspring brain development in the long term. Future studies are needed to replicate our findings and to explore the causal nature of the associations.
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spelling pubmed-96737362022-11-21 Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure Silva, Carolina C. V. Santos, Susana Muetzel, Ryan L. Vernooij, Meike W. van Rijn, Bas B. Jaddoe, Vincent W. V. El Marroun, Hanan J Am Heart Assoc Original Research BACKGROUND: Poor cardiovascular health during pregnancy has been associated with adverse neurocognitive outcomes in the offspring. We examined the associations of maternal cardiovascular health factors with brain structure in 10‐year‐old children. METHODS AND RESULTS: We included 2797 mother–offspring pairs from the Generation R Study. Maternal body mass index, gestational weight gain, blood pressure, insulin, glucose, and lipid blood concentrations were obtained in early pregnancy. Childhood structural brain measures, including global metrics of brain tissue volumes and white matter microstructure, were quantified by magnetic resonance imaging at 10 years. As compared with offspring of mothers with normal weight, those of mothers with underweight had smaller total brain volume (difference, −28.99 [95% CI −56.55 to −1.45] cm(3)). Similarly, as compared with offspring of mothers with gestational weight gain between the 25th and 75th percentile, those of mothers with gestational weight loss or no gestational weight gain (<25th percentile), had smaller total brain volume (difference, −13.07 [95% CI, −23.82 to −2.32] cm(3)). Also, higher maternal diastolic blood pressure in early pregnancy was associated with lower offspring white matter mean diffusivity (difference, −0.07 [95% CI, −0.11 to −0.02] SD score). After multiple testing correction, only the association of maternal diastolic blood pressure with lower offspring white matter mean diffusivity remained statistically significant. No associations were observed of maternal insulin, glucose, and lipid concentrations with childhood brain outcomes. CONCLUSIONS: Our findings suggest that maternal cardiovascular health during pregnancy might be related to offspring brain development in the long term. Future studies are needed to replicate our findings and to explore the causal nature of the associations. John Wiley and Sons Inc. 2022-10-03 /pmc/articles/PMC9673736/ /pubmed/36193935 http://dx.doi.org/10.1161/JAHA.122.026133 Text en © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Silva, Carolina C. V.
Santos, Susana
Muetzel, Ryan L.
Vernooij, Meike W.
van Rijn, Bas B.
Jaddoe, Vincent W. V.
El Marroun, Hanan
Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
title Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
title_full Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
title_fullStr Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
title_full_unstemmed Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
title_short Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure
title_sort maternal cardiovascular health in early pregnancy and childhood brain structure
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673736/
https://www.ncbi.nlm.nih.gov/pubmed/36193935
http://dx.doi.org/10.1161/JAHA.122.026133
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