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Structure and Function of Recombinant versus Plasma-Derived von Willebrand Factor and Impact on Multimer Pharmacokinetics in von Willebrand Disease

BACKGROUND: Recombinant von Willebrand factor (rVWF, vonicog alfa) is a purified VWF concentrate produced from Chinese hamster ovary cells. rVWF is not exposed to the VWF-cleaving protease ADAMTS13 and so is not subject to proteolytic degradation of large (L) and ultra-large (UL) VWF multimers by th...

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Detalles Bibliográficos
Autores principales:	Gritsch, Herbert, Schrenk, Gerald, Weinhappl, Nina, Mellgård, Björn, Ewenstein, Bruce, Turecek, Peter L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673800/ https://www.ncbi.nlm.nih.gov/pubmed/36405429 http://dx.doi.org/10.2147/JBM.S377126

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