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Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

The present study aimed to investigate the antitumor effect of simultaneous inhibition of dihydrofolate reductase (DHFR) enzyme. We designed some novel pyrazolo[3,4-d]pyrimidines bearing different amino acid conjugates as efficient antifolate agents attributable to their structural similarity with m...

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Detalles Bibliográficos
Autores principales:	Salem, Ibrahim M., Mostafa, Samia M., Salama, Ismail, El-Sabbagh, Osama I., Hegazy, Wael A. H., Ibrahim, Tarek S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673804/ https://www.ncbi.nlm.nih.gov/pubmed/36382444 http://dx.doi.org/10.1080/14756366.2022.2142786

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