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DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Università di Salerno
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673915/ https://www.ncbi.nlm.nih.gov/pubmed/36447744 http://dx.doi.org/10.37825/2239-9754.1032 |
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author | Rea, G. Giacobbe, G. Caroppo, D. Iovine, S. Lieto, R. Bocchino, M. Valente, T. Maglio, A. Vatrella, A. |
author_facet | Rea, G. Giacobbe, G. Caroppo, D. Iovine, S. Lieto, R. Bocchino, M. Valente, T. Maglio, A. Vatrella, A. |
author_sort | Rea, G. |
collection | PubMed |
description | Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic obstructive lung disease [1]. Recent literature papers indicate that DPO may be a predictor of pulmonary fibrosis, is related to Usual Interstitial Pneumonia (UIP) pattern, and has a higher correlation with Idiopathic Pulmonary Fibrosis (IPF). We present a case of a 41-years-old male with persistent bronchitis who underwent a chest X-ray (CXR) that showed multiple pulmonary small calcified nodules in both lungs. These findings were then defined with a high-resolution computed tomography of the chest (HRCT) that showed multiple small nodules spread in both lungs with a “tree-like pattern”. A lung biopsy was performed to confirm the radiological diagnostic hypothesis of DPO, and further pathological examination showed multifocal areas of mature bone tissue within the lung parenchyma. |
format | Online Article Text |
id | pubmed-9673915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Università di Salerno |
record_format | MEDLINE/PubMed |
spelling | pubmed-96739152022-11-28 DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge Rea, G. Giacobbe, G. Caroppo, D. Iovine, S. Lieto, R. Bocchino, M. Valente, T. Maglio, A. Vatrella, A. Transl Med UniSa Case Report Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic obstructive lung disease [1]. Recent literature papers indicate that DPO may be a predictor of pulmonary fibrosis, is related to Usual Interstitial Pneumonia (UIP) pattern, and has a higher correlation with Idiopathic Pulmonary Fibrosis (IPF). We present a case of a 41-years-old male with persistent bronchitis who underwent a chest X-ray (CXR) that showed multiple pulmonary small calcified nodules in both lungs. These findings were then defined with a high-resolution computed tomography of the chest (HRCT) that showed multiple small nodules spread in both lungs with a “tree-like pattern”. A lung biopsy was performed to confirm the radiological diagnostic hypothesis of DPO, and further pathological examination showed multifocal areas of mature bone tissue within the lung parenchyma. Università di Salerno 2021-12-23 /pmc/articles/PMC9673915/ /pubmed/36447744 http://dx.doi.org/10.37825/2239-9754.1032 Text en © 2021 Università di Salerno. https://creativecommons.org/licenses/by/2.5/This is an open access article under the CC BY 2.5 license (https://creativecommons.org/licenses/by/2.5/). |
spellingShingle | Case Report Rea, G. Giacobbe, G. Caroppo, D. Iovine, S. Lieto, R. Bocchino, M. Valente, T. Maglio, A. Vatrella, A. DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge |
title | DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge |
title_full | DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge |
title_fullStr | DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge |
title_full_unstemmed | DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge |
title_short | DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge |
title_sort | dpo: diffuse pulmonary ossification – a diagnostic challenge |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673915/ https://www.ncbi.nlm.nih.gov/pubmed/36447744 http://dx.doi.org/10.37825/2239-9754.1032 |
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