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DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge

Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with...

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Autores principales: Rea, G., Giacobbe, G., Caroppo, D., Iovine, S., Lieto, R., Bocchino, M., Valente, T., Maglio, A., Vatrella, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università di Salerno 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673915/
https://www.ncbi.nlm.nih.gov/pubmed/36447744
http://dx.doi.org/10.37825/2239-9754.1032
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author Rea, G.
Giacobbe, G.
Caroppo, D.
Iovine, S.
Lieto, R.
Bocchino, M.
Valente, T.
Maglio, A.
Vatrella, A.
author_facet Rea, G.
Giacobbe, G.
Caroppo, D.
Iovine, S.
Lieto, R.
Bocchino, M.
Valente, T.
Maglio, A.
Vatrella, A.
author_sort Rea, G.
collection PubMed
description Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic obstructive lung disease [1]. Recent literature papers indicate that DPO may be a predictor of pulmonary fibrosis, is related to Usual Interstitial Pneumonia (UIP) pattern, and has a higher correlation with Idiopathic Pulmonary Fibrosis (IPF). We present a case of a 41-years-old male with persistent bronchitis who underwent a chest X-ray (CXR) that showed multiple pulmonary small calcified nodules in both lungs. These findings were then defined with a high-resolution computed tomography of the chest (HRCT) that showed multiple small nodules spread in both lungs with a “tree-like pattern”. A lung biopsy was performed to confirm the radiological diagnostic hypothesis of DPO, and further pathological examination showed multifocal areas of mature bone tissue within the lung parenchyma.
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spelling pubmed-96739152022-11-28 DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge Rea, G. Giacobbe, G. Caroppo, D. Iovine, S. Lieto, R. Bocchino, M. Valente, T. Maglio, A. Vatrella, A. Transl Med UniSa Case Report Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic obstructive lung disease [1]. Recent literature papers indicate that DPO may be a predictor of pulmonary fibrosis, is related to Usual Interstitial Pneumonia (UIP) pattern, and has a higher correlation with Idiopathic Pulmonary Fibrosis (IPF). We present a case of a 41-years-old male with persistent bronchitis who underwent a chest X-ray (CXR) that showed multiple pulmonary small calcified nodules in both lungs. These findings were then defined with a high-resolution computed tomography of the chest (HRCT) that showed multiple small nodules spread in both lungs with a “tree-like pattern”. A lung biopsy was performed to confirm the radiological diagnostic hypothesis of DPO, and further pathological examination showed multifocal areas of mature bone tissue within the lung parenchyma. Università di Salerno 2021-12-23 /pmc/articles/PMC9673915/ /pubmed/36447744 http://dx.doi.org/10.37825/2239-9754.1032 Text en © 2021 Università di Salerno. https://creativecommons.org/licenses/by/2.5/This is an open access article under the CC BY 2.5 license (https://creativecommons.org/licenses/by/2.5/).
spellingShingle Case Report
Rea, G.
Giacobbe, G.
Caroppo, D.
Iovine, S.
Lieto, R.
Bocchino, M.
Valente, T.
Maglio, A.
Vatrella, A.
DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
title DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
title_full DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
title_fullStr DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
title_full_unstemmed DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
title_short DPO: Diffuse Pulmonary Ossification – A Diagnostic Challenge
title_sort dpo: diffuse pulmonary ossification – a diagnostic challenge
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9673915/
https://www.ncbi.nlm.nih.gov/pubmed/36447744
http://dx.doi.org/10.37825/2239-9754.1032
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